Amy E Fletcher

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BACKGROUND Huntington's disease (HD) is a rare triplet repeat (CAG) disorder. Advanced, multi-centre, multi-national research frameworks are needed to study simultaneously multiple complementary aspects of HD. This includes the natural history of HD, its management and the collection of clinical information and biosamples for research. METHODS We report(More)
Several candidate modifier genes which, in addition to the pathogenic CAG repeat expansion, influence the age at onset (AO) in Huntington disease (HD) have already been described. The aim of this study was to replicate association of variations in the N-methyl D-aspartate receptor subtype genes GRIN2A and GRIN2B in the "REGISTRY" cohort from the European(More)
PRIMARY OBJECTIVE To describe the epidemiology of traumatic brain injury (TBI) among persons 65 years of age and older in Oklahoma from 1992-2003. RESEARCH DESIGN Descriptive epidemiology of data collected through active statewide surveillance on TBI inpatient hospitalizations and fatalities. METHODS AND PROCEDURES Data collected from hospital medical(More)
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