Herbert Herzog13
Amanda Sainsbury12
Lei Zhang8
Yan-Chuan Shi8
13Herbert Herzog
12Amanda Sainsbury
8Lei Zhang
8Yan-Chuan Shi
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Peptide YY (PYY) is released following food intake and regulates intestinal function and glucose homeostasis, but the mechanisms underpinning these processes are unclear. Enteroendocrine L cells contain PYY and express the acylethanolamine receptor, Gpr119. Here, we show that Gpr119 activation inhibited epithelial electrolyte secretion in human and mouse(More)
  • Laurence Macia, Vicky Wang-Wei Tsai, Amy D. Nguyen, Heiko Johnen, Tamara Kuffner, Yan-Chuan Shi +5 others
  • 2012
Food intake and body weight are controlled by a variety of central and peripheral factors, but the exact mechanisms behind these processes are still not fully understood. Here we show that that macrophage inhibitory cytokine-1 (MIC-1/GDF15), known to have anorexigenic effects particularly in cancer, provides protection against the development of obesity.(More)
PURPOSE OF REVIEW An overview of recent developments documenting the neuropeptide Y (NPY) family's role in energy metabolism. Specifically focusing on site-specific functions of NPY and increasing evidence of peptide YY (PYY) as a weight loss therapeutic. RECENT FINDINGS Studying the NPY family in hypothalamic nuclei, other than the arcuate and(More)
  • Yan-Chuan Shi, Shu Lin, Iris P. L. Wong, Paul A. Baldock, Aygul Aljanova, Ronaldo F. Enriquez +10 others
  • 2010
BACKGROUND Y2 receptor signalling is known to be important in neuropeptide Y (NPY)-mediated effects on energy homeostasis and bone physiology. Y2 receptors are located post-synaptically as well as acting as auto receptors on NPY-expressing neurons, and the different roles of these two populations of Y2 receptors in the regulation of energy homeostasis and(More)
Gut-derived peptides are known to regulate food intake by activating specific receptors in the brain, but the target nuclei and neurons influenced are largely unknown. Here we show that peripherally administered pancreatic polypeptide (PP) stimulates neurons in key nuclei of the hypothalamus critical for appetite and satiety regulation. In the lateral(More)
Neuropeptide Y (NPY) acting in the hypothalamus is one of the most powerful orexigenic agents known. Of the five known Y receptors, hypothalamic Y1 and Y5 have been most strongly implicated in mediating hyperphagic effects. However, knockout of individual Y1 or Y5 receptors induces late-onset obesity--and Y5 receptor knockout also induces hyperphagia,(More)
  • Shu Lin, Yan-Chuan Shi, Ernie Yulyaningsih, Aygul Aljanova, Lei Zhang, Laurence Macia +5 others
  • 2009
BACKGROUND Pancreatic polypeptide (PP) is a potent anti-obesity agent known to inhibit food intake in the absence of nausea, but the mechanism behind this process is unknown. METHODOLOGY/PRINCIPAL FINDINGS Here we demonstrate that in response to i.p. injection of PP in wild type but not in Y4 receptor knockout mice, immunostaining for the neuronal(More)
  • Iris P. L. Wong, Frank Driessler, Ee Cheng Khor, Yan-Chuan Shi, Birgit Hörmer, Amy D. Nguyen +5 others
  • 2012
BACKGROUND & AIMS Gastrointestinal peptides are increasingly being linked to processes controlling the maintenance of bone mass. Peptide YY (PYY), a gut-derived satiety peptide of the neuropeptide Y family, is upregulated in some states that also display low bone mass. Importantly, PYY has high affinity for Y-receptors, particularly Y1R and Y2R, which are(More)
Recruitment of activated immune cells into white adipose tissue (WAT) is linked to the development of insulin resistance and obesity, but the mechanism behind this is unclear. Here, we demonstrate that Y1 receptor signaling in immune cells controls inflammation and insulin resistance in obesity. Selective deletion of Y1 receptors in the hematopoietic(More)
BACKGROUND Gout is an arthritic condition that is characterised by extremely painful, debilitating acute attacks and eventual joint and organ damage if not controlled. Despite the availability of very effective therapies that, if adhered to, will prevent acute attacks and long-term damage, the disorder is increasingly prevalent. There is an urgent need to(More)