Amrita Singh Chandhoke

Learn More
Tumor metastasis contributes to the grave morbidity and mortality of cancer, but the mechanisms underlying tumor cell invasiveness and metastasis remain incompletely understood. Here, we report that expression of the SUMO E3 ligase PIAS1 suppresses TGFβ-induced activation of the matrix metalloproteinase MMP2 in human breast cancer cells. We also find that(More)
Transforming growth factor-beta (TGFβ) is a secreted polypeptide that plays essential roles in cellular development and homeostasis. Although mechanisms of TGFβ-induced responses have been characterized, our understanding of TGFβ signaling remains incomplete. Here, we uncover a novel function for the protein kinase NDR1 (nuclear Dbf2-related 1) in TGFβ(More)
Identification of a novel link between the protein kinase NDR1 and TGFβ signaling in epithelial cells. Abstract Transforming growth factor-beta (TGFb) is a secreted polypeptide that plays essential roles in cellular development and homeostasis. Although mechanisms of TGFb-induced responses have been characterized, our understanding of TGFb signaling remains(More)
  • 1