Amrita B. Hazra
Highly Influential Citations7
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Cobamides are members of the vitamin B12 family of cofactors that function in a variety of metabolic processes and are synthesized only by prokaryotes. Cobamides produced by different organisms vary… Continue Reading
Cobamides such as vitamin B12 (cobalamin) are produced exclusively by prokaryotes and used by many other organisms as cofactors for diverse metabolic processes. Cobamides are cobalt-containing… Continue Reading
Thiamin pyrophosphate is an important cofactor in all forms of life, where it plays a central role in the stabilization of the acyl-carbanion biosynthon1, 2. Its biosynthesis involves separate… Continue Reading
In Saccharomyces cerevisiae , thiamin pyrimidine is formed from histidine and pyridoxal phosphate (PLP). The origin of all of the pyrimidine atoms has been previously determined using labeling… Continue Reading
This mini review covers recent advances in the mechanistic enzymology of cofactor biosynthesis.
We investigated perchlorate (ClO4−) and chlorate (ClO3−) (collectively (per)chlorate) in comparison with nitrate as potential inhibitors of sulfide (H2S) production by mesophilic sulfate-reducing… Continue Reading
In many bacteria tenI is found clustered with genes involved in thiamin thiazole biosynthesis. However, while TenI shows high sequence similarity with thiamin phosphate synthase, the purified protein… Continue Reading
Cobamides, which include vitamin B₁₂ (cobalamin), are a class of modified tetrapyrroles synthesized exclusively by prokaryotes that function as cofactors for diverse biological processes. Cobamides… Continue Reading
In this paper, we describe an optimized reconstitution of the thiamin thiazole synthase (ThiG) catalyzed reaction and demonstrate that the enzymatic product is an unanticipated dearomatized thiazole… Continue Reading
Abstract Ab initio calculations at second-order Moeller–Plesset (MP2) level with 6-31++G(d,p) basis set have been done on the intermolecular complexes of HCHY ( Y = O , S ) with LiCl. Ten possible… Continue Reading