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  • Amrita B. Hazra, Jennifer L A Tran, Terence S. Crofts, Michiko E Taga
  • Biology, Medicine
  • Chemistry & biology
  • 2013 (First Publication: 1 October 2013)
  • Cobamides such as vitamin B12 (cobalamin) are produced exclusively by prokaryotes and used by many other organisms as cofactors for diverse metabolic processes. Cobamides are cobalt-containingContinue Reading
  • Abhishek Chatterjee, Amrita B. Hazra, Sameh H. Abdelwahed, David G. Hilmey, Tadhg P Begley
  • Medicine, Chemistry
  • Angewandte Chemie
  • 2010 (First Publication: 8 November 2010)
  • Thiamin pyrophosphate is an important cofactor in all forms of life, where it plays a central role in the stabilization of the acyl-carbanion biosynthon1, 2. Its biosynthesis involves separateContinue Reading
  • Amrita B. Hazra, Abhishek Chatterjee, Tadhg P Begley
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 2009 (First Publication: 11 March 2009)
  • In this paper, we describe an optimized reconstitution of the thiamin thiazole synthase (ThiG) catalyzed reaction and demonstrate that the enzymatic product is an unanticipated dearomatized thiazoleContinue Reading