Amna Jabbar Siddiqui

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BACKGROUND Large scale usage of tobacco causes a lot of health troubles in human. Various formulations of tobacco are extensively used by the people particularly in developing world. Besides several toxic tobacco constituents some metals and metalloids are also believed to pose health risks. This paper describes inductively coupled plasma-mass spectrometric(More)
For the comprehensive metabolite profiling of human plasma, sample preparation is a crucial step. In this investigation, we have compared 10 different extraction techniques for metabolite profiling by GC-MS. Six one-dimensional (1D) and four two-dimensional (2D) extraction techniques involving solvent precipitation, molecular weight cut off tube (MWCOT) and(More)
Acute leukemia is a critical neoplasm of white blood cells. In order to differentiate between the metabolic alterations associated with two subtypes of acute leukemia, acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), we investigated the serum of ALL and AML patients and compared with two controls (healthy and aplastic anemia) using (1)H(More)
In this study, a quantitative method was developed based on gas chromatography triple quadrupole mass spectrometry (GC-QQQ-MS) for the analysis of aroma component of mango sap (latex) in nine Pakistani varieties that are Anmol, Began pali, Badami, Caroba, Chaunsa, Lal patra, Neelum, Sohnara and Tota pari. The non-aqueous phase of sap was studied and a total(More)
Honey is synthesized from flower nectar and it is famous for its tremendous therapeutic potential since ancient times. Many factors influence the basic properties of honey including the nectar-providing plant species, bee species, geographic area, and harvesting conditions. Quality and composition of honey is also affected by many other factors, such as(More)
BACKGROUND Metabolomics is a real challenge owing to the complexity and chemical heterogeneity of biological samples. In this study, a comparative analysis of metabolite profiling using ten metabolite extraction techniques were investigated on a pooled plasma sample followed by direct infusion ESI-MS analysis on both positive and negative modes. Methodology(More)
Oral cancer is a major health challenge in the Indian subcontinent and a dreadful form of cancers worldwide. The current study is focused on the identification of distinguished metabolites of oral cancer tissue samples in comparison with precancerous and control tissue samples using gas chromatography coupled with triple quadrupole tandem mass spectrometry(More)
β-Thalassemia is one of the most prevalent forms of congenital blood disorders characterized by reduced hemoglobin levels with severe complications, affecting all dimensions of life. The mechanisms underlying the phenotypic heterogeneity of β-thalassemia are still poorly understood. We aimed to work over metabolite biomarkers to improve mechanistic(More)
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