Amit Kulkarni

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The performance of the site-features docking algorithm LibDock has been evaluated across eight GlaxoSmithKline targets as a follow-up to a broad validation study of docking and scoring software (Warren, G. L.; Andrews, W. C.; Capelli, A.; Clarke, B.; Lalonde, J.; Lambert, M. H.; Lindvall, M.; Nevins, N.; Semus, S. F.; Senger, S.; Tedesco, G.; Walls, I. D.;(More)
A methodology termed membrane-interaction QSAR (MI-QSAR) analysis has been developed in order to predict the behavior of organic compounds interacting with the phospholipid-rich regions of biological membranes. One important application of MI-QSAR analysis is to estimate ADME properties including the transport of organic solutes through biological membranes(More)
There has been much recent interest in adding support for real-time capabilities to Android. Proposed architectures for doing so fall into four broad categories, but only two support real-time Android applications. These two proposals include a real-time garbage collector for real-time memory management and a real-time operating system for real-time(More)
An automated E-Novo protocol designed as a structure-based lead optimization tool was prepared through Pipeline Pilot with existing CHARMm components in Discovery Studio. A scaffold core having 3D binding coordinates of interest is generated from a ligand-bound protein structural model. Ligands of interest are generated from the scaffold using an R-group(More)
This paper presents RTDroid, a variant of Android that provides predictability to Android applications. Although there has been much interest in adopting Android in real-time contexts, surprisingly little work has been done to examine the suitability of Android for real-time systems. Existing work only provides solutions to traditional problems, including(More)
This paper models the default probabilities and credit spreads for select Indian firms in the Black-Scholes-Merton framework. Counter to previous research, we show that the objective (or ‘real’) probability estimates are higher than the risk-neutral estimates over the sample period. However, the probability measure is found to be robust to the ‘default(More)
The 9-valent Human Papillomavirus (HPV) vaccine, 9vHPV, was licensed in the U.S. in December, 2014. We assessed healthcare provider (HCP) awareness of the newly approved vaccine and identified questions HCPs have about the vaccine. As part of a larger study, we used semi-structured interviews to ask 22 pediatric HCPs about their awareness of 9vHPV,(More)
OBJECTIVE To investigate the clinical and economic impacts of school-based administration of the quadrivalent HPV vaccine. METHODS A retrospective health-economic analysis was conducted using data collected in Singapore between 2004 and 2005. A dynamic transmission model was adapted for universal vaccination that provided 80% coverage among students aged(More)
Objectives. This study evaluated community pharmacists’ confidence in their knowledge regarding the advances in the human genome project (HGP) and determined their requirements for education and training on this subject. Methods. A survey was administered to community pharmacists (N=377) working in the Houston Metropolitan Area using a convenient sampling(More)