Amit K. Jha

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The current investigation aimed to develop a biomimetic, three-dimensional (3D) culture system for poorly adherent bone metastatic prostate cancer cells (C4-2B) for use as an in vitro platform for anti-cancer drug screening. To this end, hyaluronic acid (HA) derivatives carrying complementary aldehyde (HAALD) and hydrazide (HAADH) groups were synthesized(More)
We have generated a bioinspired tunable system of hyaluronic acid (HyA)-based hydrogels for Matrix-Assisted Cell Transplantation (MACT). With this material, we have independently evaluated matrix parameters such as adhesion peptide density, mechanical properties, and growth factor sequestering capacity, to engineer an environment that imbues donor cells(More)
In a distributed storage system (DSS), high data reliability is obtained by dispersing the data over a number of nodes over a network. In an (n, k) erasure code based DSS, a data file is first divided into k packets and then these k packets are encoded into n packets using an MDS code, and finally these n packets are distributed over n nodes so that each(More)
Osteogenic differentiation of human mesenchymal stem cells (hMSCs) is guided by various physical and biochemical factors. Among these factors, modulus (i.e., rigidiy) of the ECM has gained significant attention as a physical osteoinductive signal that can contribute to endochondral ossification of a cartilaginous skeletal template. However, MSCs also(More)
Novel, clinically relevant, approaches to shift energy balance are urgently needed to combat metabolic disorders such as obesity and diabetes. One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 and thus can uncouple mitochondrial respiration from ATP synthesis. While expansion of UCP1-expressing(More)
Anti-VEGF drugs that are used in conjunction with laser ablation to treat patients with diabetic retinopathy suffer from short half-lives in the vitreous of the eye resulting in the need for frequent intravitreal injections. To improve the intravitreal half-life of anti-VEGF drugs, such as the VEGF decoy receptor sFlt-1, we developed multivalent(More)
the printing process. Previously, patterning of liquid metals by direct writing [9] and filling predefined microchannels has been demonstrated. [10–12] Furthermore, the use of liquid metal as conductors, [13,14] capacitors, [15] and antennas [16–24] has been shown. The illustrated circuit and sensor applications include embedded elastomer conductors, [13](More)
Purpose To investigate the biocompatibility of an injectable hydrogel and its ability to control myopia progression in guinea pigs. Methods The study used a hydrogel synthesized from acrylated hyaluronic acid with a conjugated cell-binding peptide and enzymatically degradable crosslinker. Seven-day-old guinea pigs were first form deprived (FD) with(More)
This paper is the implementation of private cloud software as service server; centralized remote accessibility and data storage system without internet connection in Microsoft windows server 2K8 with domain controlling. Migrating from a traditional model to the Cloud model reduce cost for enterprise customer. The main objectives of Saas provider are to(More)
One of the major hurdles to widespread usage of application whitelisting with today's dynamically changing and updating software's; is the static environment it creates that leaves little scope for changes to the system once whitelisting is enforced. The de-facto method to allow for trusted changes to system is to make selected executable files as trusted(More)