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Colorectal cancer (CRC) screening tests often have a trade-off between efficacy and patient acceptability/cost. Fecal tests (occult blood, methylation) engender excellent patient compliance but lack requisite performance underscoring the need for better population screening tests. We assessed the utility of microRNAs (miRNAs) as markers of field(More)
Microscopic colitis is currently considered to harbor no increased risk for colorectal cancer, based on a few small studies with limited long-term follow-up. Our aim was to identify patients with microscopic colitis, and to compare long-term rates of colorectal cancer or adenoma to a control group of patients without microscopic colitis. We reviewed the(More)
Inspired by the cheetah, we present a novel tail control system for manoeuvring terrestrial robots at high speed. The mathematic model for a high-speed turn is derived and the model with a tail is shown to be more successful at rapid turns in simulation. We then built a high speed mobile platform with an actuated tail to experimentally validate the control(More)
Stimulated by recent biomechanics research of the cheetah, a novel tail controller system for rapid acceleration and braking is presented. To understand the targeted behaviour of a cheetah performing a longitudinal manoeuvre and the effects an actuated tail has, a simple mathematical template was developed. Subsequently feedback controllers were designed(More)
This paper presents a novel approach to achieving aerial pitch righting in a mobile robot, inspired by the draglines used by jumping spiders. We developed and simulated a mathematical model of the spider during the aerial phase of its jump to gain further insight into the factors affecting the pitch response. The results demonstrate that the dragline could(More)
An actuated tail can impart large angular impulse over short time spans, but swinging in a plane results in inevitable tail angle saturation. Cheetahs (Acinonyx jubatus) are observed swinging the tail in a cone during turns [1], and this paper develops a simplified two-degree-of-freedom (pitch and roll) rigid tail model to investigate this motion.(More)
Head and neck squamous cell carcinoma (HNSCC) is a major cause of morbidity and mortality underscoring the need for safe and effective chemopreventive strategies. Targeting epidermal growth factor receptor (EGFR) is attractive in that it is an early critical event in HNSCC pathogenesis. However, current agents lack efficacy or have unacceptable toxicity.(More)
During high-speed pursuit of prey, the cheetah (Acinonyx jubatus) has been observed to swing its tail while manoeuvring (e.g. turning or braking) but the effect of these complex motions is not well understood. This study demonstrates the potential of the cheetah's long, furry tail to impart torques and forces on the body as a result of aerodynamic effects,(More)
Hyperemesis gravidarum (HG) may be defined as persistent, unexplained nausea and vomiting resulting in more than 5% weight loss, abnormal fluid and nutritional intake, electrolyte imbalance, dehydration, and ketonuria [1]. Symptoms often extend beyond the first trimester and can last throughout the entire pregnancy in as many as one-third of cases, leading(More)
Animals are able to accelerate rapidly from rest with incredible dexterity but these transient motions are poorly understood. Here we present the first examination of the time optimal behaviour of a quadruped sprinting from rest. We develop a planar multi-body model and employ modern trajectory optimization methods to produce a motion without prescribing(More)