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OBJECTIVE The aim of this study was to evaluate the regional effects of type 2 diabetes and associated conditions on cerebral tissue volumes and cerebral blood flow (CBF) regulation. RESEARCH DESIGN AND METHODS CBF was examined in 26 diabetic (aged 61.6 +/- 6.6 years) and 25 control (aged 60.4 +/- 8.6 years) subjects using continuous arterial spin(More)
In this work, computational methods were utilized to optimize the field produced by the transverse electromagnetic (TEM) resonator in the presence of the human head at 8 Tesla. Optimization was achieved through the use of the classical finite difference time domain (FDTD) method and a TEM resonator loaded with an anatomically detailed human head model with(More)
B(1) Field inhomogeneity and the relative effects of dielectric resonances are analyzed within the context of ultra high field MRI. This is accomplished by calculating the electromagnetic fields inside spherical phantoms and within a human head model in the presence and absence of an RF coil. These calculations are then compared to gradient echo and RARE(More)
PURPOSE To evaluate if magnetic susceptibility sensitive phase postprocessed images can be used to enhance the inherent brain/gray white matter contrast in gradient echo (GE) images at 8-Tesla (T) magnetic resonance (MR). MATERIALS AND METHODS Phase and magnitude images of high-resolution GE MR 8-T images were created. Comparisons were made between the(More)
To examine effects of aging and endurance training on human muscle metabolism during exercise, 31P magnetic resonance spectroscopy was used to study the metabolic response to exercise in young (21-33 yr) and older (58-68 yr) untrained and endurance-trained men (n = 6/group). Subjects performed graded plantar flexion exercise with the right leg, with(More)
Plantar flexor torque was measured in 24 young (25 +/- 1.4 y) and older (62 +/- 2 y) untrained and endurance-trained men to test the hypothesis that age-associated declines in muscle function would be attenuated in older men who also endurance trained. Endurance-trained subjects averaged 7-9 h/wk of aerobic activity for 10-12 years. These subjects had not(More)
A systematic analysis of the effect of an 8.0 tesla static magnetic field on physiological and/or cognitive function is presented in the normal volunteer and in the swine. A study of ten human subjects revealed no evidence of detectable changes in body temperature, heart rate, respiratory rate, systolic pressure, and diastolic blood pressure after 1 hour of(More)
The wrists of asymptomatic volunteers were imaged at 8 and 1.5 T. The signal-to-noise ratio, spatial resolution, and soft tissue contrast of the 8 T images were much greater. The increased signal-to-noise ratio available at 8 T allows acquisition of high quality, high resolution images and visualization of intricate anatomy at scan times acceptable for(More)
Objective. To determine the feasibility of acquiring in vivo images of the human carpal tunnel at 8 tesla (T). Design. The wrist of an asymptomatic volunteer was imaged with an 8 T /80 cm magnet. The subject was imaged prone with the arm over the head and the wrist placed in neutral position in a custom-built dedicated shielded wrist coil. Axial(More)
In this work, we present the first human magnetic resonance image (MRI) obtained at ultrahigh field strengths (8 T). We demonstrate that clinical imaging will be possible at 8 T and that reasonable quality head images can be obtained at this field strength. Most importantly, we emphasize that the power required to excite the spins at 8 T is much lower than(More)