Learn More
OBJECTIVE The aim of this study was to evaluate the regional effects of type 2 diabetes and associated conditions on cerebral tissue volumes and cerebral blood flow (CBF) regulation. RESEARCH DESIGN AND METHODS CBF was examined in 26 diabetic (aged 61.6 +/- 6.6 years) and 25 control (aged 60.4 +/- 8.6 years) subjects using continuous arterial spin(More)
PURPOSE To evaluate if magnetic susceptibility sensitive phase postprocessed images can be used to enhance the inherent brain/gray white matter contrast in gradient echo (GE) images at 8-Tesla (T) magnetic resonance (MR). MATERIALS AND METHODS Phase and magnitude images of high-resolution GE MR 8-T images were created. Comparisons were made between the(More)
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, resulting in physical, cognitive and affective disturbances, with notable declines in the ability to learn and retain new information. In this study, we examined if higher levels of physical activity in MS individuals were associated with an increased resting-state(More)
PURPOSE High resolution MR images obtained from a normal human volunteer at 8 T are utilized to describe the appearance of iron-containing deep gray nuclei at this field strength. METHOD High resolution (1,024 x 1,024 matrix) near-axial gradient echo images of the deep gray nuclei were acquired on a human volunteer by using an 8 T scanner. The images were(More)
A recently developed ultra high field MRI system operating at 8 T (UHFMRI) was applied for brainstem imaging. UHFMRI was performed in five healthy volunteers (three men, two women; age range 34--46 years). Sagittal and axial slices were obtained with the following settings: GE, TR 750--1,000 ms, TE 7-9 ms, FOV 20 cm, matrix 1,024 x 1,024 or 512 x 512(More)
OBJECTIVE To determine acute effects of intranasal insulin on regional cerebral perfusion and cognition in older adults with type 2 diabetes mellitus (DM). RESEARCH DESIGN AND METHODS This was a proof-of-concept, randomized, double-blind, placebo-controlled intervention evaluating the effects of a single 40-IU dose of insulin or saline on vasoreactivity(More)
Recent research and theory has highlighted the dynamic nature of amygdala activation. Rather than simply being sensitive to a few limited stimulus categories, amygdala activation appears to be dependent on the goals of the perceiver. In this study, we extend this line of work by demonstrating that the means by which a person seeks to accomplish a goal also(More)
OBJECTIVE Diabetes increases the risk for cerebromicrovascular disease, possibly through its effects on blood flow regulation. The aim of this study was to assess the effects of type 2 diabetes on blood flow velocities (BFVs) in the middle cerebral arteries and to determine the relationship between white matter hyperintensities (WMHs) on magnetic resonance(More)
A decrease in interaction between brain regions is observed in individuals with autism spectrum disorder (ASD), which is believed to be related to restricted neural network access in ASD. Propranolol, a beta-adrenergic antagonist, has revealed benefit during performance of tasks involving flexibility of access to networks, a benefit also seen in ASD. Our(More)
PURPOSE Magnetic susceptibility provides the basis for functional studies and image artifacts in MRI. In this work, magnetic susceptibility and the associated artifacts were analyzed at 8 T in phantoms and in the human head. METHOD A mineral oil phantom was constructed in which three cylindrical air-filled tubes were inserted. This phantom was analyzed(More)