Amir Ali Shoro

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MicroRNA-21 (miR-21) located on 17q23.1 expressed in breast cancer has anti-apoptotic ability and causes tumor cell growth. It is also involved in functions such as signal transduction pathways effecting normal cell growth and differentiation. The primary objective of the study was to identify presence of miR-21 in the serum levels of stage III invasive(More)
MicroRNAs (miRs) are non-coding ribonucleic acids consisting of about 18-22 nucleotide bases. Expression of several miRs can be altered in breast carcinomas in comparison to healthy breast tissue, or between various subtypes of breast cancer. These are regulated as either oncogene or tumor suppressors, this shows that their expression is misrepresented in(More)
Aims: To evaluate the protective role of melatonin and insulin on the morphology of proximal convoluted tubules(PCT) of albino rats made nephrotoxic by a chemotherapeutic drug like streptozotocin (STZ). Study design: Prospective experimental study. Place and duration of study: Department of Anatomy, Basic Medical Sciences Institute (BMSI), Jinnah Post(More)
  • Amir Ali Shoro
  • Methods and findings in experimental and clinical…
  • 1981
In Britain alone about 2,400 infants (0.3 percent of total live births) are born with spina bifida each year. Nearly half of these die at or shortly after birth, but a great majority of the remainder who survive are seriously handicapped. Many attempts have been made in the past to diagnose such cases early enough in pregnancy so that timely termination of(More)
Intra-uterine growth retardation and limb deformities, resembling clubfoot, were produced by tubocuararine chloride, and by toxiferine, when administered to the rat fetus between the 16th and 19th day of gestation. These effects were associated in some fetuses, but were not sex-linked. Fetuses in the middle part of the uterine horn were observed to be more(More)
  • Amir Ali Shoro
  • Methods and findings in experimental and clinical…
  • 1981
The data from previous experimental work were analysed and indicated a positive correlation between the placental weight and fetal weight and placental size and fetal size of the rat fetuses affected by intra-uterine administration of neuromuscular blocking agents. Various factors capable of affecting the fetal size and weight were considered. The results(More)
OBJECTIVE To analyse micro ribonucleic acid-16 in sera of invasive intraductal breast carcinoma in stage III and compare its expression in their daughters and healthy women. METHODS The study took place from January 2013 till December 2015. This case-control study was conducted at the Ziauddin Cancer Hospital, Karachi, and comprised breast cancer patients(More)
Background: In experimental animal models, Streptozotocin (STZ) causes hypertrophy and disruption of the layers of adrenal cortex, and administration of melatonin protects the adrenal cortex damaged by stress-induced oxidative damage. Aim: To observe the effect of melatonin on the body weight, serum glucose and ACTH, and morphology of adrenal cortex in STZ(More)