Amintas Fabiano de Souza Figueiredo

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Hydrolysis of D-valyl-L-leucyl-L-lysine 4-nitroanilide (1), D-valyl-L-leucyl-L-arginine 4-nitroanilide (2), and N alpha-p-tosyl-L-arginine methyl ester (3) by human tissue kallikrein was studied throughout a wide range of substrate concentrations. At low substrate concentrations, the hydrolysis followed Michaelis-Menten kinetics but, at higher substrate(More)
OBJECTIVE To evaluate the possible relationship between the human tissue kallikrein amidase activity with sex and ethnicity in Brazilian primary hypertensive patients. DESIGN Population-based study. PARTICIPANTS One hundred men and women, Black and White primary hypertensive patients aged 20 years and older were selected. Eighty nine healthy(More)
The American Diabetes Association and the National Kidney Foundation define microalbuminuria as an albumin (microg)/creatinine (mg) ratio (ACR) between 30 and 300 microg/mg regardless of sex. Microalbuminuria is associated with increased cardiovascular risk. The authors evaluated the prevalence of microalbuminuria in nondiabetic and nonhypertensive systolic(More)
BACKGROUND Human tissue kallikrein (hK1) is a key enzyme in the kallikrein-kinin system (KKS). hK1-specific amidase activity is reduced in urine samples from hypertensive and heart failure (HF) patients. The pathophysiologic role of hK1 in coronary artery disease (CAD) remains unclear. OBJECTIVE To evaluate hK1-specific amidase activity in the urine of(More)
Human tissue kallikrein (hK1) is reduced in hypertension, cardiovascular and renal diseases. There is little information on the participation of hK1 in type 1 diabetes mellitus (DM), type 2 DM, and gestational diabetes mellitus (GDM), respectively. The aim of this study was to evaluate the roles of insulin and hyperglycemia on urinary hK1 activity in type 1(More)
SCALING-UP OF THE PROCEDURE FOR THE PURIFICATION OF HUMAN URINARY KALLIKREIN URINARY KALLIKREIN AMINTAS F. S. FIGUEIREDO and MARCOS MARES-GUIA Department of Biochemistry, Faculty of Medicine, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil The purification of human urinary kallikrein described by Hial et al. (Biochemistry 13, 4311, 1974) is being(More)
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