Amina Bibi

Hajer Siala2
Taieb Messaoud2
Abdelhedi Miled1
Fekria Ouennich1
Slaheddine Fattoum1
2Hajer Siala
2Taieb Messaoud
1Abdelhedi Miled
1Fekria Ouennich
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BACKGROUND The protein tyrosine phosphatase-1B, a negative regulator for insulin and leptin signalling, potentially modulates glucose and energy homeostasis. PTP1B is encoded by the PTPN1 gene located on chromosome 20q13 showing linkage with type 2 diabetes (T2D) in several populations. PTPN1 gene variants have been inconsistently associated with T2D, and(More)
UNLABELLED Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder caused by a genetic defect in alpha-L-iduronidase (IDUA) which is involved in the degradation of dermatan and heparan sulfates. The disease has severe and milder phenotypic subtypes. The aim of this study was the detection of mutations in the IDUA gene from(More)
Hereditary persistence of fetal hemoglobin (HPFH) is a group of genetically heterogeneous conditions characterized by continued expression of fetal hemoglobin (HbF) in adulthood. HPFH may be due not only to point mutations or large deletions in different regions of the cluster β globin, but also to variations in several polymorphic sequences in this(More)
The apolipoprotein E (APOE) is a well-established risk factor for late-onset Alzheimer’s disease (AD). Several studies have attempted to confirm the association between the polymorphism located at position −491 in the transcriptional regulatory region of the APOE gene and AD. We examined in 85 AD patients and 90 control subjects of a Tunisian population the(More)
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