Amie B Mclain

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We investigated the effects of an acute bout of neuromuscular electrical stimulation-induced resistance exercise (NMES-RE) on intracellular signaling pathways involved in translation initiation and mechanical loading-induced muscle hypertrophy in spinal cord-injured (SCI) versus able-bodied (AB) individuals. AB and SCI individuals completed 90 isometric(More)
The mechanisms underlying poor glucose tolerance in persons with spinal cord injury (SCI), along with its improvement after several weeks of neuromuscular electrical stimulation-induced resistance exercise (NMES-RE) training, remain unclear, but presumably involve the affected skeletal musculature. We, therefore, investigated skeletal muscle signaling(More)
Individuals with long-standing spinal cord injury (SCI) often present with extreme muscle atrophy and impaired glucose metabolism at both the skeletal muscle and whole body level. Persistent inflammation and increased levels of proinflammatory cytokines in the skeletal muscle are potential contributors to dysregulation of glucose metabolism and atrophy;(More)
STUDY DESIGN Two randomized, double-blind, placebo-controlled trials. OBJECTIVE To evaluate the efficacy and safety of fampridine sustained-release tablets (fampridine-SR) 25 mg twice daily for moderate-to-severe spasticity in patients with chronic spinal cord injury (SCI). SETTING United States and Canada. METHODS Patients with incomplete chronic SCI(More)
STUDY DESIGN Cross-sectional study. OBJECTIVES To assess whether T11-L2 sensation is significantly associated with perception of bladder filling and whether S3-S5 sensation is significantly associated with potential for voluntary voiding after spinal cord injury (SCI). SETTING Alabama, United States. METHODS A total of 79 men and women with SCI, and(More)
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