Amelia Sacristán

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A dose of 5 microCi of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) (methyl 14C) was administered to mice. Animals were sacrificed 10 days after administration and their brain and cerebellum isolated for autoradiography and electron microscopy. Sections were prepared in such a manner that a general topographic assignment of radioactivity(More)
The direct action of 7-chloro-3-[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy- methyl]benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32-2) on the membrane integrity of C. albicans is studied by quantifying the leakage of intracellular adenosine triphosphate (ATP) into the medium as an index of the changes in membrane permeability and integrity(More)
In this work, the bioavailability of the 14C-methyl-labelled cytidine diphosphate choline (CDP-Choline, citicoline, Somazina), has been studied by oral route, leading to the result that it is slowly and completely absorbed, with a very low urinary and fecal elimination, thus producing maintained blood levels. The bioavailability related to oral route(More)
The LD50 and LD0 of choline HCl and cytidine diphosphate choline (CDP-choline, citicoline, Somazina) by oral and intravenous route at equivalent doses of choline for both compounds were determined. The qualitative and quantitative analysis of the results obtained lead to the conclusion that choline shows a remarkable cholinergic action, while CDP-choline(More)
Oral administration of 14C methyl CDP-choline in Sprague-Dawley rats provided the following data: --Radioactivity from cytidine diphosphate choline (CDP-choline, citicoline, Somazina) is found in the brain at a high rate. --62.8% of total radioactivity measured in the brain is found as a part of phospholipids. --This radioactivity is detected by the(More)
Two groups of rats were administered by oral route doses of 100 and 150 mg/kg, respectively, of cytidine diphosphate choline (CDP-choline citicoline, Somazina), daily during 30 days. At the end of the test, animals were killed and necropsied, evaluating the urinary, haematological, serum biochemistry and histopathological parameters. The study did not(More)
A single oral dose of 1.5 g/kg cytidine diphosphate choline (CDP-choline, citicoline, Somazina) was administered to 6 Beagle dogs daily for 6 months. After treatment period, treated animals as well as control animals were sacrificed and assessment of urinalysis, blood analysis and histopathological studies were made. Results were found within normal(More)