Amelia A. Mutso

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Chronic pain patients exhibit increased anxiety, depression, and deficits in learning and memory. Yet how persistent pain affects the key brain area regulating these behaviors, the hippocampus, has remained minimally explored. In this study we investigated the impact of spared nerve injury (SNI) neuropathic pain in mice on hippocampal-dependent behavior and(More)
The hippocampus has been shown to undergo significant changes in rodent models of neuropathic pain; however, the role of the hippocampus in human chronic pain and its contribution to pain chronification have remained unexplored. Here we examine hippocampal processing during a simple visual attention task. We used functional MRI to identify intrinsic and(More)
Previous studies found that neuron specific enolase promoter (Nse-BMP4) transgenic mice have increased expression of the nociceptive mediator, substance P and exaggerated local injury responses associated with heterotopic ossification (HO). It is of interest great to know the pain responses in these mice and how the opioid signaling is involved in the(More)
It has been recently demonstrated that pain behavior in the mouse can be modulated by the presence of a conspecific, but what remains unclear is whether such pain behavior can serve the function of soliciting social approach. Using a novel social approach paradigm, we tested mice in various dyadic or triadic conditions, including "jailed" mice-some in pain(More)
Sarcosine is a competitive inhibitor of glycine type 1 transporter. We hypothesized that it may have analgesic and anti-neuropathic efficacy by a dual action: affecting neurotransmission in the prefrontal cortex as well as within the spinal cord. In rats with spared nerve injury (SNI) oral sarcosine reduced mechanical sensitivity for the injured limb(More)
The full role of adult hippocampal neurogenesis (AHN) remains to be determined, yet it is implicated in learning and emotional functions, and is disrupted in negative mood disorders. Recent evidence indicates that AHN is decreased in persistent pain consistent with the idea that chronic pain is a major stressor, associated with negative moods and abnormal(More)
3 Introduction 4 Empathy 5 Pain 7 Human Empathy Research 10 Animal Empathy Research 14 Affiliation 18 Oxytocin and Vasopressin 18 Sex Differences 24 Present Study 25 Implications of Research 29 Method Subjects 30 Materials 30 Procedures 31 Results Experiment One 32 Experiment Two 35 Cross-Experiment 36 Discussion 39 Theoretical Implications 43 Future(More)
Reorganization of Hippocampal Functional Connectivity with 1 Transition to Chronic Back Pain 2 3 4 Amelia A. Mutso, Bogdan Petre, Lejian Huang, Marwan N. Baliki,Souraya Torbey, Kristina Herrmann, 5 Thomas J. Schnitzer and A. Vania Apkarian 6 7 Departments of Physiology,Physical Medicine and Rehabilitation, Anesthesia and Surgery, Feinberg 8 School of(More)
BACKGROUND Commercially available pedometers have been used as tools to measure endpoints in studies evaluating physical activity promotion programs. However, their accuracy in patients recovering from COPD exacerbations is unknown. The objectives of this study were to 1) assess the relative accuracy of different commercially available pedometers in healthy(More)
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