Ameeruddin Nusrath Unissa

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AccD6 (acetyl coenzyme A (CoA) carboxylase), plays an important role in mycolic acid synthesis of Mycobacterium tuberculosis (Mtb). Induced gene expression by isoniazid (isonicotinylhydrazine - INH), anti-tuberculosis drug) shows the expression of accD6. It is our interest to study the binding of activated INH with the AccD6 model using molecular docking(More)
Mutation at codon 315 of katG gene is the major cause for isoniazid (INH) resistance in Mycobacterium tuberculosis (M. tuberculosis). Substitution at codon 315 of katG gene was analyzed in 85 phenotypically resistant isolates collected from various parts of southern India by direct sequencing method. The obtained results were interpreted in the context of(More)
Isoniazid, an important drug in the anti-tuberculosis therapy, the enzyme catalase-peroxidase (KatG) plays a key role in activating isoniazid (INH). Mutation in katG gene is a major mechanism of INH resistance in M. tuberculosis. Several derivatives of INH show activity against TB and multi-drug resistant TB. With the aim of finding new compounds, in this(More)
Despite the availability of various techniques for diagnosis; the presence of improved and modified version of vaccines and the existence of more than a dozen of drugs, tuberculosis still remains as a significant infectious disease. The publication of complete genome of Mycobacterium tuberculosis has lead to the development of new genetic tools to ascertain(More)
Pyrazinamide (PZA)-an important drug in the anti-tuberculosis therapy, activated by an enzyme Pyrazinamidase (PZase). The basis of PZA resistance in Mycobacterium tuberculosis (Mtb) is owing to mutation in pncA gene coding for PZase. The identification of the structural or functional defects in the mutant enzymes leading to resistance still remains an area(More)
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