• Publications
  • Influence
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
TLDR
A potent peptide aldehyde inhibitor has been developed and shown to prevent apoptotic events in vitro, suggesting that apopain/CPP32 is important for the initiation of apoptotic cell death. Expand
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
TLDR
It is demonstrated that ATR/ATM-dependent phosphorylation of hRad17 is a critical early event during checkpoint signalling in DNA-damaged cells. Expand
Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.
TLDR
PP5 plays an essential role in the activation and checkpoint signaling functions of ATM in cells that have suffered DNA double-strand breaks, and a direct regulatory linkage between PP5 and ATM is reported. Expand
Protein Phosphatase 5 Is Required for ATR-Mediated Checkpoint Activation
TLDR
It is demonstrated that protein phosphatase 5 (PP5) is required for the ATR-mediated checkpoint activation and reduced PP5 activity exerts differential effects on the formation of intranuclear foci by ATR and replication protein A, implicating a functional role for PP5 in a specific stage of the checkpoint signaling pathway. Expand
Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases (*)
TLDR
Cysteine proteases related to mammalian interleukin-1β-converting enzyme (ICE) and the nematode cell death abnormal ced-3 gene product and two novel members of this new family of ICE/CED-3-related proteases were cloned from human monocytic cells and may participate in proteolytic events culminating in the apoptotic death of human cells. Expand
Effects of Salinity and Mixed Ammonium and Nitrate Nutrition on the Growth and Nitrogen Utilization of Barley
The absorption and utilization of nitrogen (N) by plants are affected by salinity and the form of N in the root medium. A hydroponic study was conducted under controlled conditions to investigateExpand
Improvement of rice drought tolerance through backcross breeding: Evaluation of donors and selection in drought nurseries
TLDR
These drought-selected introgression lines represent a useful genetic resource to develop improved cultivars for farmers in rainfed or water-scarce rice-growing regions, and also to improve the understanding of the genetic and molecular basis of drought tolerance in rice. Expand
Hidden diversity for abiotic and biotic stress tolerances in the primary gene pool of rice revealed by a large backcross breeding program
TLDR
Three large sets of introgression lines are developed, which not only provide an unique platform of breeding materials for developing new rice cultivars with superior yield and stability by trait/gene pyramiding, but also represent unique genetic stocks for a large-scale discovery of genes/alleles underlying the abiotic and biotic stress tolerances of rice using genomic tools. Expand
Evidence for involvement of tumor necrosis factor‐α in apoptotic death of bone marrow cells in myelodysplastic syndromes
TLDR
The presence of TNF‐ α–inducible apoptotic DNA fragmentation pattern in MDS supports its involvement in these disorders and suggests that anti–TNF‐α (or anticytokine) therapy may be of special benefit to MDS patients, where no definitive treatment is yet available. Expand
Correlation of tumor necrosis factor α (TNFα) with high Caspase 3-like activity in myelodysplastic syndromes
TLDR
The present studies identify the downstream effectors of TNFα-inducible apoptosis in MDS and so also the suppressors ofTNFα apoptotic signaling and the effects of different Caspase inhibitors and pentoxifylline on TNF α-induced apoptosis were evaluated. Expand
...
1
2
...