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The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility Index.
OBJECTIVES A P-value <0.05 is one metric used to evaluate the results of a randomized controlled trial (RCT). We wondered how often statistically significant results in RCTs may be lost with smallExpand
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High-volume hemofiltration for septic acute kidney injury: a systematic review and meta-analysis
IntroductionHigh-volume hemofiltration (HVHF) is an attractive therapy for the treatment of septic acute kidney injury (AKI). Small experimental and uncontrolled studies have suggested hemodynamicExpand
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Generic immunosuppression in solid organ transplantation: systematic review and meta-analysis
Objective To compare the clinical efficacy and bioequivalence of generic immunosuppressive drugs in patients with solid organ transplants. Design Systematic review and meta-analysis of all studiesExpand
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Lower serum magnesium is associated with vascular calcification in peritoneal dialysis patients: a cross sectional study
BackgroundCoronary artery calcification (CAC) is highly prevalent among dialysis patients and is associated with increased cardiovascular and all cause mortality. Magnesium (Mg) inhibits vascularExpand
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Factors Associated with Unplanned Dialysis Starts in Patients followed by Nephrologists: A Retropective Cohort Study
The number of patients starting dialysis is increasing world wide. Unplanned dialysis starts (patients urgently starting dialysis in hospital) is associated with increased costs and high morbidityExpand
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Statin use associates with a lower incidence of acute kidney injury after major elective surgery.
Statins abrogate ischemic renal injury in animal studies but whether they are renoprotective in humans is unknown. We conducted a population-based retrospective cohort study that included 213,347Expand
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The Risk of Major Hemorrhage with CKD.
New staging systems for CKD account for both reduced eGFR and albuminuria; whether each measure associates with greater risk of hemorrhage is unclear. In this retrospective cohort study (2002-2010),Expand
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Warfarin and the Risk of Stroke and Bleeding in Patients With Atrial Fibrillation Receiving Dialysis: A Systematic Review and Meta-analysis.
BACKGROUND Patients with atrial fibrillation who receive dialysis are at a high risk of ischemic stroke. The role of warfarin in mitigating this risk in patients with atrial fibrillation who receiveExpand
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Association of postoperative proteinuria with AKI after cardiac surgery among patients at high risk.
BACKGROUND AND OBJECTIVES Preoperative proteinuria is associated with a higher incidence of postoperative AKI. Whether the same is true for postoperative proteinuria is uncertain. This study testedExpand
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Association between angiotensin converting enzyme inhibitor or angiotensin receptor blocker use prior to major elective surgery and the risk of acute dialysis
BackgroundSome studies but not others suggest angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) use prior to major surgery associates with a higher risk ofExpand
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