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BACKGROUND Activation of the liver x receptors (LXRs) by exogenous ligands stimulates the degradation of beta-amyloid 1-42 (Abeta42), a peptide that plays a central role in the pathogenesis of Alzheimer's disease (AD). The oxidized cholesterol products (oxysterols), 24-hydroxycholesterol (24-OHC) and 27-hydroxycholesterol (27-OHC), are endogenous activators(More)
In a double blind study twelve class I probands received occlusal splints with six different customized anterior guidances. The subjective feelings were rated using a psychologic scale. It was shown, that splints with a large "a" were better rated than splints with a small "a". "a" is the radius of the maximal curvature of the sagittal anterior tooth(More)
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