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Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction.
Pyrroloiminoquinone alkaloid alkaloids are a novel class of HIF-1α inhibitors, which interrupt the protein-protein interaction between Hif-1 α and p300 and consequently reduce H IF-related transcription.
neo-Clerodane diterpenoids from Ajuga bracteosa.
Different neo-clerodane diterpenoids were isolated from a dichloromethane extract of Ajuga bracteosa depending on the isolation procedure used, owing to the labile nature of these tetrahydrofurofuran
Phytoecdysteroids from Ajuga macrosperma var. breviflora roots.
Three new phytoecdysteroids, ajugacetalsterones C (1) and D (3) and breviflorasterone (2), were isolated from the roots of Ajuga macrosperma var. breviflora along with five known compounds, namely,
LC-MS-SPE-NMR for the isolation and characterization of neo-clerodane diterpenoids from Teucrium luteum subsp. flavovirens (perpendicular).
The present work describes for the first time the application of the LC-MS-SPE-NMR technique for the isolation and characterization of three new neo-clerodane diterpenes, 3beta-hydroxyteucroxylepin and teuluteumin A and teulinumin B, from Teucrium luteum subsp.
Stelliosphaerols A and B, Sesquiterpene-Polyol Conjugates from an Ecuadorian Fungal Endophyte.
New sesquiterpene-polyol conjugates that are responsible, at least in part, for the S. aureus inhibitory activity of the fungal extract are identified.
neo-Clerodane Diterpenoids from Ajuga macrosperma var. breviflora
Six new naturally occurring ajugarin-like neo-clerodane diterpenoids, ajugaflorins A-F, along with six known compounds, were isolated from A. breviflora by extensive NMR spectroscopic and MS analyses and comparison with data previously reported.
Phytotoxic Activity of Flavonoids from Dicranostyles Ampla
Two phytotoxic flavonoids were found to be responsible for much of the activity of the extract as a whole in the A. stolonifera and L. sativa bioassay, and Dicranostyles ampla Ducke were among the most active of those species tested.
Neo-Clerodane Diterpenoids from Verbenaceae: Structural Elucidation and Biological Activity
This review focuses on the occurrence and structural elucidation of neo-clerodane type diterpenes from Verbenaceae (no matter if recently reclassified based on phylogenetic research) and the