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Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits.
The beneficial effects of physical activity (PA) are well documented, yet the mechanisms by which PA prevents disease and improves health outcomes are poorly understood. To identify major gaps inExpand
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Sustained Calcium Entry through P2X Nucleotide Receptor Channels in Human Airway Epithelial Cells*
Purinergic receptor stimulation has potential therapeutic effects for cystic fibrosis (CF). Thus, we explored roles for P2Y and P2X receptors in stably increasing [Ca2+] i in human CF (IB3-1) andExpand
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Extracellular Zinc and ATP Restore Chloride Secretion across Cystic Fibrosis Airway Epithelia by Triggering Calcium Entry*
Cystic fibrosis (CF) is caused by defective cyclic AMP-dependent cystic fibrosis transmembrane conductance regulator Cl- channels. Thus, CF epithelia fail to transport Cl- and water. A postulatedExpand
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Delayed Fracture Healing in Growth Differentiation Factor 5-deficient Mice: A Pilot Study
BackgroundGrowth differentiation factor-5 (GDF-5) is a key regulator of skeletogenesis and bone repair and induces bone formation in spinal fusions and nonunion applications by enhancing chondrocyticExpand
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Extracellular ATP-Gated P2X Purinergic Receptor Channels
Publisher Summary This chapter discusses the aspects of extracellular adenosine triphosphate (ATP)-gated P2X purinergic receptor channels. It was known for decades that the application of ATP as anExpand
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