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Mesenchymal stromal cell therapy for the treatment of intestinal ischemia: Defining the optimal cell isolate for maximum therapeutic benefit.
Intestinal ischemia is a devastating intraabdominal emergency that often necessitates surgical intervention. Mortality rates can be high, and patients who survive often have significant long-termExpand
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Vascular endothelial growth factor: therapeutic possibilities and challenges for the treatment of ischemia.
Vascular endothelial growth factor (VEGF) is a notable chemokine that plays critical roles in angiogenesis and vasculogenesis. The contemporary body of literature contains a substantial amount ofExpand
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Hydrogen sulfide improves intestinal recovery following ischemia by endothelial nitric oxide-dependent mechanisms.
Hydrogen sulfide (H2S) is an endogenous gasotransmitter that has vasodilatory properties. It may be a novel therapy for intestinal ischemia-reperfusion (I/R) injury. We hypothesized that 1) H2S wouldExpand
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Human mesenchymal stromal cells decrease mortality after intestinal ischemia and reperfusion injury.
BACKGROUND Cellular therapy is a novel treatment option for intestinal ischemia. Bone marrow-derived mesenchymal stromal cells (BMSCs) have previously been shown to abate the damage caused byExpand
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Harvest tissue source does not alter the protective power of stromal cell therapy after intestinal ischemia and reperfusion injury.
BACKGROUND Transplantation of mesenchymal stromal cells (MSCs) may be a novel treatment for intestinal ischemia. The optimal stromal cell source that could yield maximal protection after injury,Expand
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Hydrogen Sulfide: A Potential Novel Therapy for the Treatment of Ischemia
ABSTRACT Hydrogen sulfide (H2S) is a novel signaling molecule most recently found to be of fundamental importance in cellular function as a regulator of apoptosis, inflammation, and perfusion.Expand
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Human Adipose Stromal Cells Increase Survival and Mesenteric Perfusion Following Intestinal Ischemia and Reperfusion Injury
Objective: Intestinal ischemia can quickly escalate to bowel necrosis and perforation. Transplantation of stem cells presents a novel treatment modality for this problem. We hypothesized that: humanExpand
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Impact of integrated programs on general surgery operative volume.
BACKGROUND Integrated residencies are now commonplace, co-existing with categorical general surgery residencies. The purpose of this study was to define the impact of integrated programs onExpand
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Hydrogen sulfide provides intestinal protection during a murine model of experimental necrotizing enterocolitis.
BACKGROUND Necrotizing enterocolitis (NEC) continues to be a morbid surgical condition among preterm infants. Novel therapies for this condition are desperately needed. Hydrogen sulfide (H2S) is anExpand
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Direct peritoneal resuscitation improves survival and decreases inflammation after intestinal ischemia and reperfusion injury.
BACKGROUND Direct peritoneal resuscitation (DPR) has previously been shown to alter blood flow in the small bowel mesenteric vessels in models of intestinal ischemia. However, a survival advantage orExpand
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