Amanda L. Halfond

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Genetic changes required for the formation and progression of human Schwann cell tumors remain elusive. Using a Sleeping Beauty forward genetic screen, we identified several genes involved in canonical Wnt signaling as potential drivers of benign neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs). In human neurofibromas and MPNSTs,(More)
Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that occur spontaneously, or from benign plexiform neurofibromas, in the context of the genetic disorder Neurofibromatosis Type 1 (NF1). The current standard treatment includes surgical resection, high-dose chemotherapy, and/or radiation. To date, most targeted therapies have failed(More)
Adrienne L. Watson 1,2,4,5 , Eric P. Rahrmann 1,2,4,5 , Branden S. Moriarity 1,2,4,5 , Kwangmin Choi 8,10 , Caitlin B. Conboy 1 , Andrew D. Greeley 1,2 , Amanda L. Halfond 6 , Leah K. Anderson 2 , Brian R. Wahl 2 , Vincent W. Keng 1,2,4,5,13 , Anthony E. Rizzardi 3,12 , Colleen L. Forster 7 , Margaret H. Collins9,10, Aaron L. Sarver 1 , Margaret R. Wallace(More)
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