Amanda Jamieson

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Salmeterol inhaled twice-daily is now being used more frequently as additional treatment in asthma insufficiently controlled by inhaled corticosteroids. We compared oral bambuterol in a dose of 20 mg taken once daily in the evening with inhaled salmeterol at 50 microgram taken twice daily in 126 asthmatic patients (60 bambuterol, 66 salmeterol) aged 18 to(More)
Three biochemical gene markers test the hypothesis that the European hake, Merluccius merluccius (L.), along the west European continental shelf are one race. The three polymorphic loci were serum transferrin (Tf), eye vitreous fluid butyric esterase (Es) and liver superoxide dismutase (Sod). Five transferrin alleles, three esterase alleles and two(More)
BACKGROUND Dysphonia is a known local adverse effect of inhaled corticosteroids. This symptom was investigated by laryngoscopy and assessment in a voice laboratory. The effects of changing the treatment of patients with dysphonia, reported whilst using the pMDI, to pMDI plus Nebuhaler or Tubuhaler was also assessed. METHODS Seventy-two patients reporting(More)
OBJECTIVE This study was carried out in order to assess whether AS patients are adversely affected by a "good" night's sleep accompanied by little nocturnal movement. METHODS Objective and subjective nocturnal movement, flexibility, stiffness, pain and psychomotor performance were measured in 22 subjects, 11 with ankylosing spondylitis and 11 controls. (More)
PURPOSE To establish a HPLC assay for plasma losartan and its active metabolite EXP3174 to facilitate clinical pharmacokinetic studies. METHODS the HPLC system consisted of a 250 x 2 mm i.d. C18 reversed phase column preceded by a 4 x 4 mm guard column, a UV detector set at 254 nm, and an integrator. The mobile phase was a mixture of 0.01 M ammonium(More)
Cationic lipid-DNA (CL-DNA) complexes were recently found to exhibit a novel multilamellar structure composed of alternating lipid bilayer and DNA monolayer with distinct interhelical DNA spacings (Rädler et al. Science 1997, 275, 810). We report on the aggregation behavior, morphology, and interfacial properties related to the solution structure of(More)
The aim of the study was to compare the bronchodilatory effect of 2x50 microg salbutamol inhaled via Turbuhaler(R) as two consecutive doses compared with two divided doses (50+50 microg) at different time intervals. The study was of a randomized, double-blind, crossover design. The patients inhaled two doses of 50 microg salbutamol immediately after each(More)
A minimum fresh gas flow of 1 litre per minute per mask and an inspired concentration of 2-3% halothane was required in induce anesthesia in rats in 1-2 min. Anaesthesia was maintained with an inspired concentration of 1.5-2% halothane. Arterial carbon dioxide concentration increased during anaesthesia and was reduced by increasing the flow of fresh gas.(More)