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Rats treated chronically with delta 9-tetrahydrocannabinol (THC, daily oral dose 20 mg/kg) were examined for residual effects on a variety of behaviors following a 1-4-month drug-free period. Learning a 12-arm radial maze and a differential reinforcement of low-rate responding (DRL-20) task was significantly retarded in THC-treated animals, although(More)
Neuroimaging investigations reliably describe a left-lateralized network of areas as underlying the representations of knowledge about familiar tools. Among the critical 'nodes' of the network, an area centered within the left intraparietal sulcus (IPS) is thought to be related to the motoric representations associated with familiar tools and their usage.(More)
Naive food-restricted and food-satiated rats were given a choice between ethanol (8%, 16%, or 32%) and water for 22 hours/day over 14 days. On all days and at all concentrations, intakes of ethanol were significantly higher in the food-restricted animals. Doses consumed by these animals were highest when 32% ethanol was used, with a mean daily intake of(More)
Chronic oral administration of cannabis extract to rats (daily delta 9-tetrahydrocannabinol dose 20 mg/kg) was examined in three experiments for its residual effect on radial-arm maze learning following a 1-month drug-free period. Learning a simple eight-arm maze was significantly impaired in rats treated for either 6 months (Experiment I) or 3 months(More)
Mature rats (starting weight at least 270 g) were treated daily with cannabis extract (daily THC dose 20 mg/kg) for 3 months. After a 1- to 4-month drug-free period, residual effects on a variety of behaviors were studied. No residual effects were found in learning of an eight-arm radial maze task, nor on a differential reinforcement of low-rate responding(More)
Chronic oral administration of cannabis extract to rats was examined for its residual effects on shuttle-box avoidance learning. In experiment 1 avoidance learning was assessed in rats that had been tested previously on other behavioral tests. Chronic treatment (3 months) facilitated the learning of shuttle-box avoidance in cannabis-treated animals relative(More)
Patients who are unable to ingest adequate nutrients by oral intake present a common challenge for family physicians. Feeding difficulties can be caused by many factors, including anatomic, neurologic, and gastrointestinal dysfunction. Long-term nutritional support options include parenteral feeding and percutaneous enteral access. Nasogastric tubes are(More)
Chronic oral administration of cannabis extract to rats (daily delta 9-tetrahydrocannabinol dose 20 mg/kg) was examined for its residual effect on open field activity and DRL (differential reinforcement of low-rat responding) performance, following a 2-3 month drug-free period. Locomotor activity during the latter part of an open field test was markedly(More)
OBJECTIVE To determine the rate of Helicobacter pylori eradication following bismuth-based triple therapy with colloidal bismuth subcitrate, tetracycline hydrochloride and metronidazole. PATIENTS AND METHODS One hundred and eleven patients were randomly assigned, in a two to one ratio, to colloidal bismuth subcitrate 120 mg qid plus metronidazole 250 mg(More)
Unilateral lesions of various medial forebrain bundle components were assessed for their effects on lateral hypothalamic self-stimulation. Damage of areas containig nigrostriatal dopaminergic or ascending noradrenergic neurons had negligible effects on bar pressing, tail moving and alley running for hypothalamic stimulation. Lesions which appeared to(More)