Amanda J. Kedaigle

Learn More
High-throughput 'omic' methods reveal many aspects of cellular state and biological responses to perturbations. However, no single data type is capable of fully representing the cellular activity. Beyond the list of molecules from each data type, there is a necessity to consider multiple data jointly and reconstruct the relations between these molecules(More)
Brain microvascular endothelial cells (BMECs) are an essential component of the blood-brain barrier (BBB) that shields the brain against toxins and immune cells. While BBB dysfunction exists in neurological disorders, including Huntington's disease (HD), it is not known if BMECs themselves are functionally compromised to promote BBB dysfunction. Further,(More)
With the recent technological developments a vast amount of high-throughput data has been profiled to understand the mechanism of complex diseases. The current bioinformatics challenge is to interpret the data and underlying biology, where efficient algorithms for analyzing heterogeneous high-throughput data using biological networks are becoming(More)
  • 1