Amanda J. Hall

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Since the publication of the human reference genome, the identities of specific genes associated with human diseases are being discovered at a rapid rate. A central problem is that the biological activity of these genes is often unclear. Detailed investigations in model vertebrate organisms, typically mice, have been essential for understanding the(More)
An ideal test for identifying shifts in cochlear function would be highly repeatable and sensitive to minor damage. Three types of otoacoustic emission (OAE) test and pure-tone audiometry were evaluated for this purpose. They were compared in terms of test-retest repeatability within subjects and sensitivity to differences between subjects. The OAE measures(More)
This study examined changes in rhythmic arm shaking and laterality biases in infants observed longitudinally at three points: just prior to, at, and just following reduplicated babble onset. Infants (ranging in age from 4 to 9 months at babble onset) were videotaped at home as they played with two visually identical audible and silent rattles presented at(More)
Pseudomonas aeruginosa is the most common bacterial pathogen infecting the lungs of patients with cystic fibrosis (CF). The Liverpool Epidemic Strain (LES) is transmissible, capable of superseding other P. aeruginosa populations and is associated with increased morbidity. Previously, multiple inducible prophages have been found to coexist in the LES(More)
The present study explored illness perceptions of hearing difficulties amongst one hundred participants who reported experiencing hearing difficulties despite normal audiometric thresholds. This experience is referred to as King-Kopetzky syndrome (KKS), obscure auditory dysfunction (OAD), or auditory processing disorder (APD). Logistic regression was used(More)
The retinal anterior homeobox (rax) gene encodes a transcription factor necessary for vertebrate eye development. rax transcription is initiated at the end of gastrulation in Xenopus, and is a key part of the regulatory network specifying anterior neural plate and retina. We describe here a Xenopus tropicalis rax mutant, the first mutant analyzed in detail(More)
OBJECTIVE To investigate the association of prenatal alcohol exposure with balance in10-year-old children. DESIGN Population-based prospective longitudinal study. SETTING Former Avon region of UK (Southwest England). PARTICIPANTS 6915 children from the Avon Longitudinal Study of Parents and Children who had a balance assessment at age 10 and had data(More)
OBJECTIVES To determine the carrier rate of the GJB2 mutation c.35delG and c.101T>C in a UK population study; to determine whether carriers of the mutation had worse hearing or otoacoustic emissions compared to non-carriers. DESIGN Prospective cohort study. SETTING University of Bristol, UK. PARTICIPANTS Children in the Avon Longitudinal Study of(More)
Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this,(More)
OBJECTIVES To compare oral health and hearing outcomes from the Clinical Standards Advisory Group (CSAG, 1998) and the Cleft Care UK (CCUK, 2013) studies. SETTING AND SAMPLE POPULATION Two UK-based cross-sectional studies of 5-year-olds born with non-syndromic unilateral cleft lip and palate undertaken 15 years apart. CSAG children were treated in a(More)