Amanda Arulpragasam

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We compared the effects of intravitreal injection of bi-cistronic adeno-associated viral (AAV-2) vectors encoding enhanced green fluorescent protein (GFP) and either ciliary neurotrophic factor (CNTF), brain-derived neurotrophic factor (BDNF) or growth-associated protein-43 (GAP43) on adult retinal ganglion cell (RGC) survival and regeneration following (i)(More)
Over a century ago, hypertrophy of astrocytes was noted as a pathology of multiple sclerosis (MS) and was hypothesized to play an important role in this disease, yet the contribution of astrocytes has been largely underemphasized in the pathophysiology of CNS demyelination. Astrocytes perform many homeostatic functions within the developing and adult CNS,(More)
Based on aqueous redox chemistry and simple in vivo models of oxidative stress, Escherichia coli and Saccharomyces cerevisiae, the cationic Mn(III) N-substituted pyridylporphyrins (MnPs) have been identified as the most potent cellular redox modulators within the porphyrin class of drugs; their efficacy in animal models of diseases that have oxidative(More)
Indian Journal of Endocrinology and Metabolism | Volume 21 | March 2017 | ESICON 2016 Abstracts S2 Primary testicular failure: A search for ideal biomarkers Ashutosh Halder, Prashant Kumar, Manish Jain Reproductive Biology, AIIMS, New Delhi, India. E-mail: Background: Primary testicular failure (hypergonadotropic hypogonadism)(More)