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Mechanisms underlying resistance to cetuximab in the HNSCC cell line: role of AKT inhibition in bypassing this resistance.
EGFR is frequently overexpressed in head and neck squamous cell cancer (HNSCC). Cetuximab is a monoclonal antibody designed to interact with EGFR, block its activation, reduce the downstreamExpand
New Insights into How Yersinia pestis Adapts to Its Mammalian Host during Bubonic Plague
TLDR
The results suggest that (i) intracellular survival during the early stage of infection is important for plague and (ii) horizontal gene transfer was crucial in the acquisition of this ability. Expand
A refined model of how Yersinia pestis produces a transmissible infection in its flea vector
TLDR
The present results highlight the physiopathological and molecular mechanisms leading to flea blockage, show that the role of a gene like rpiA changes in space and in time during an infection, and emphasize that evolution is a gradual process punctuated by sudden jumps. Expand
Circulating thrombospondin 1 level as a surrogate marker in patients receiving cyclophosphamide-based metronomic chemotherapy
TLDR
The TSP-1 level driven by MC did not correlate to clinical benefit and was stable in patients receiving megestrol acetate, indicating that thrombospondin may be a mediator of the antiangiogenic effects of low-dose metronomic cyclophosphamide-based chemotherapy. Expand
Cilengitide targets pediatric glioma and neuroblastoma cells through cell detachment and anoikis induction
TLDR
Cilengitide’s action on glioma and neuroblastoma cells appears to be dependent on &agr;v&bgr;3 expression and sensitivity to anoikis, and tumor context could validate these promising observations. Expand
Nutrient depletion may trigger the Yersinia pestis OmpR‐EnvZ regulatory system to promote flea‐borne plague transmission
TLDR
The data suggest that the flea gut is a complex, fluctuating environment in which Y. pestis senses nutrient depletion via OmpR‐EnvZ and triggers a molecular program that produces the biofilm required for efficient plague transmission. Expand
Evaluation of the Role of the opgGH Operon in Yersinia pseudotuberculosis and Its Deletion during the Emergence of Yersinia pestis
TLDR
The results suggest an evolutionary scenario whereby an ancestral Yersinia strain lost a factor required for OPG biosynthesis but kept opgGH (to regulate cell size) because OpgH-dependent cell size control became unnecessary. Expand
Polymorphism in the Yersinia LcrV Antigen Enables Immune Escape From the Protection Conferred by an LcrV-Secreting Lactococcus Lactis in a Pseudotuberculosis Mouse Model
TLDR
It is shown that an anti-LcrV-based vaccine should contain multiple LcrV clades if protection against the widest possible array of Yersinia strains is sought and key polymorphic residues responsible for the absence of cross-protection are highlighted. Expand
Synergistic Effect of SN-38 in Combination with Cetuximab on Angiogenesis and Cancer Cell Invasion.
TLDR
SN-38/cetuximab combination has synergistic anti-angiogenesis and anti-invasion activities mediated by down-regulation of phosphatidylinositol-3-kinases/AKT and mitogen-activated protein kinase/ERK pathways. Expand
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