Alyssa Glass

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For individually motivated agents to work collaboratively to satisfy shared goals, they must make decisions about actions and intentions that take into account their commitments to group activities. This paper examines the role of social consciousness in the process of reconciling intentions to do group-related actions with other, conflicting intentions. We(More)
We present an overview+detail document interface that draws on perceptual principles to help users work with documents. Central to our approach is the use of improved document overviews. Our approach also includes novel highlighting in the full representation of documents, as well as techniques to help users smoothly transition from the overview to the full(More)
LIGHT is a tumor necrosis factor (TNF) ligand superfamily member, which binds two known cellular receptors, lymphotoxin-beta receptor (LTbetaR) and the herpesvirus entry mediator (HveA). LIGHT is a homotrimer that activates proapoptotic and integrin-inducing pathways. Receptor binding residues via LIGHT were identified by introducing point mutations in the(More)
Cytotoxic T cells secrete perforin to kill virus-infected cells. In this study we show that perforin also plays a role in immune regulation. Perforin-deficient (perf -/-) mice chronically infected with lymphocytic choriomeningitis virus (LCMV) contained greater numbers of antiviral T cells compared to persistently infected +/+ mice. The enhanced expansion(More)
Ovine trophoblast protein-1 (oTP-1), the major product secreted by the trophectoderm of the sheep conceptus between days 13 and 21 of pregnancy, is considered to mediate maternal recognition of pregnancy by maintaining the function of the corpus luteum. Its amino acid sequence has 40-55% identity with various mammalian interferons-alpha (IFN-alpha), and it(More)
Platelet membrane GPIIb-IIIa is a member of the integrin family of heterodimeric adhesion receptors. Processing and export of certain leukocyte and melanoma integrins is disrupted in cells lacking one subunit. We found that surface expression of GPIIb-IIIa, measured by fluorescent activated cell sorting or by surface labeling, required cotransfection of(More)
With growing opportunities for individually motivated agents to work collaboratively to satisfy shared goals, it becomes increasingly important to design agents that can make intelligent decisions in the context of commitments to group activities. In particular, agents need to be able to reconcile their intentions to do group-related actions with other,(More)
The ligand-binding function of integrin adhesion receptors depends on divalent cations. A mutant alpha IIb beta 3 integrin (platelet gpIIb/IIIa) that lacks ligand recognition shows immunologic evidence of a perturbed interaction with divalent cations. This was found to be caused by a G----T mutation that resulted in an Asp119----Tyr119 substitution in the(More)