Alyssa A Borders

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BACKGROUND AND PURPOSE The formation of reactive astrocytes is common after central nervous system injuries such as stroke. However, the signaling pathway(s) that control astrocyte formation and functions are poorly defined. We assess the effects of Notch 1 signaling in peri-infarct-reactive astrocytes after stroke. METHODS We examined reactive astrocyte(More)
Damage to the medial temporal lobes produces profound amnesia, greatly impairing the ability of patients to learn about new associations and events. While studies in rodents suggest a strong link between damage to the hippocampus and the ability to navigate using distal landmarks in a spatial environment, the connection between navigation and memory in(More)
The medial temporal lobe (MTL) is critical for binding together different attributes that together form memory for prior episodes, but whether it is preferentially involved in supporting specific types of associations is a topic of much debate. Some have argued that the MTL, specifically the hippocampus, may be specialized for binding information from(More)
The medial temporal lobe (MTL) plays a critical role in episodic long-term memory, but whether the MTL is necessary for visual short-term memory is controversial. Some studies have indicated that MTL damage disrupts visual short-term memory performance whereas other studies have failed to find such evidence. To account for these mixed results, it has been(More)
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