Alyson J. Smith

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The mechanism by which the proapoptotic Bcl-2 family members Bax and Bak release cytochrome c from mitochondria is incompletely understood. In this paper, we show that activator BH3-only proteins bind tightly but transiently to the Bak hydrophobic BH3-binding groove to induce Bak oligomerization, liposome permeabilization, mitochondrial cytochrome c(More)
Past research suggests that choice in deciding the features of a task can enhance performance. Independent of the quality of performance, choice may also increase the actor’s confidence by providing a secondary source of subjective control during the task. In two studies designed to examine this augmentation hypothesis, college students were asked to read(More)
Previous studies have suggested that the BH3 domain of the proapoptotic Bcl-2 family member Noxa only interacts with the anti-apoptotic proteins Mcl-1 and A1 but not Bcl-2. In view of the similarity of the BH3 binding domains of these anti-apoptotic proteins as well as recent evidence that studies of isolated BH3 domains can potentially underestimate the(More)
Recently we reported that the BH3-only proteins Bim and Noxa bind tightly but transiently to the BH3-binding groove of Bak to initiate Bak homo-oligomerization. However, it is unclear how such tight binding can induce Bak homo-oligomerization. Here we report the ligand-induced Bak conformational changes observed in 3D models of Noxa·Bak and Bim·Bak refined(More)
According to the cultural trade-off hypothesis, individualism and collectivism entail inverse costs and benefits for the two dimensions of global self-esteem. Specifically, individualism is described as promoting the development of self-competence but inhibiting the development of self-liking. Collectivism is described as doing the opposite. To examine the(More)
Pluripotent stem cells have been the focus of bioengineering efforts designed to generate regenerative products, yet harnessing therapeutic capacity while minimizing risk of dysregulated growth remains a challenge. The risk of residual undifferentiated stem cells within a differentiated progenitor population requires a targeted approach to eliminate(More)
In addressing the mental health of international students, individualism-collectivism is treated as a dimension of cultural distance that produces differential sensitivity to life events. A collectivist cultural orientation is hypothesized to promote depressive dysphoria in response to negative social events and to increase the inhibitory effect of positive(More)
Human induced pluripotent stem cells (hiPSC) hold great promise in diagnostic and therapeutic applications. However, translation of hiPSC technology depends upon a means of assessing hiPSC quality that is quantitative, high-throughput, and can decipher malignant teratocarcinoma clones from normal cell lines. These attributes are lacking in current(More)
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