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Hypoxic pulmonary vasoconstriction is the elegant theory put forward more than six decades ago to explain regional variations in perfusion within the lung in certain animal species in response to localised restrictions in oxygenation. Although considerable progress has been made to describe the phenomenon at the macroscopic level and explain it at the(More)
Running Title: PAR 2 induces inflammatory events in fibroblasts. Abstract Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors, of which PAR 2 , has been implicated in inflammatory airways disease. Although fibroblasts are pathologically important in the airways, the pro-inflammatory role of PAR 2 in these cells currently(More)
BACKGROUND Cough recordings have been undertaken for many years but the analysis of cough frequency and the temporal relation to trigger factors have proven problematic. Because cough is episodic, data collection over many hours is required, along with real-time aural analysis which is equally time-consuming. A method has been developed for the automatic(More)
BACKGROUND The pathogenesis of chronic cough is not well understood and treatment options are limited. In this study we sought to explore the current understanding and management of chronic cough across an international group of specialists. METHODS This was an international study of cross sectional qualitative design. In depth interviews were carried out(More)
BACKGROUND Chronic cough is a common symptom which causes significant levels of morbidity. It is becoming increasingly well characterised by research taking place in specialist cough clinics, where successful treatment rates are high. However, there is a paucity of data regarding the symptom complex of chronic cough in the community. This report details the(More)
nucleus of the Working Group on Pulmonary Circulation and Right Ventricular Function and approved by the ESC Board at its meeting on 17 June 1997 upon the recommendation of the Committee for Scientific and Clinical Initiatives. This Task Force consists of 21 Members, including representatives of the European Respiratory Society, the European Association of(More)
Cough is the commonest symptom of clinical importance and the most frequent reason for new consultations with a doctor. Although therapy directed at any underlying cause for cough can be effective there is a clinical need for new treatments specifically directed at the cough itself. A major obstacle to the development of such therapy has been an imprecise(More)
The effect of inhibition of angiotensin-converting enzyme (ACE) on standard cough challenge was investigated in a double-blind, randomised study in sixteen normal volunteers. Captopril (25 mg) or matched placebo was given by mouth 2 h before inhalation of nebulised distilled water, citric acid, and incremental doses of capsaicin (0.5-20 mumol/l). Distilled(More)
Chronic cough has been suggested to be due to three conditions, asthma, post nasal drip, and reflux disease. A different paradigm has evolved in which cough is viewed as the primary condition characterised by afferent neuronal hypersensitivity and different aspects of this syndrome are manifest in the different phenotypes of cough. There are several(More)