Aly Richardson

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6517 Background: Tosedostat is a novel oral aminopeptidase inhibitor which has shown promising efficacy in elderly relapsed/refractory AML (Lowenberg 2010). OPAL will provide additional data from a more tightly defined patient population and explore different dosing regimens. METHODS OPAL is a single-arm study of 73 AML patients aged >60 years who had a(More)
Carotid endarterectomy (CEA) surgery is performed using regional anesthesia and intravenous/sedative drugs, such as dexmedetomidine and remifentanil. It is unclear which drug provides the least amount of hemodynamic variability, sedation, and respiratory depression so cognitive function can be continuously monitored intraoperatively. A search of the(More)
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