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Risk of venous thromboembolism (VTE) is elevated in cancer, but individual risk factors cannot identify a sufficiently high-risk group of outpatients for thromboprophylaxis. We developed a simple model for predicting chemotherapy-associated VTE using baseline clinical and laboratory variables. The association of VTE with multiple variables was characterized(More)
PURPOSE Hemostatic activation is common in pancreatic cancer and may be linked to angiogenesis and venous thromboembolism. We investigated expression of tissue factor (TF), the prime initiator of coagulation, in noninvasive and invasive pancreatic neoplasia. We correlated TF expression with vascular endothelial growth factor (VEGF) expression, microvessel(More)
OBJECTIVE Studies have shown improved survival in cancer patients treated with low molecular weight heparins (LMWHs). Tumors depend on an expanding vasculature, and heparins may affect vessel growth and function. We investigated the effect of heparins differing in Mr on selected endothelial cell properties. METHODS AND RESULTS Human umbilical vein(More)
Venous thromboembolism (VTE) is a known complication of cancer which impacts on patient mortality and quality of life. Despite the known deleterious effects of VTE, the benefits of thromboprophylaxis have not been fully established. Identification of patients at highest risk of VTE could lead to better targeting of thromboprophylaxis. Several risk factors(More)
BACKGROUND This study examines venous thromboembolism (VTE)-associated resource utilization and real-world costs in ambulatory patients initiating chemotherapy for selected common high-risk solid tumors. METHODS Health care claims data (2004-2009) from the IMS/PharMetrics(®) Patient-Centric database were collected for propensity score-matched adult cancer(More)
and class III obesity. Mean follow-up was 17 months. No significant difference was found in demographics studied except BMI. No significant difference was found in flap complications among all groups, including super obese women. However, patients with BMI > 35 were associated with higher rates of reoperation for surgical correction compared to patients(More)
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