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A mathematical description of the regulation of ATP production in muscle cells is presented whereby the activity of OxP can be calculated as a function of (1) free [ADP] as the substrate and (2) a second driving force ΦΔG (kilojoules per mole) resulting from the difference of free energy ΔG ox,ap (kilojoules per mole)–ΔG ATP,cyt (kilojoules per mole). In(More)
The balance between protein synthesis and degradation, and between active skeletal muscle cell hypertrophy and atrophy can be described as a function of protein degradation rate by a transcription-translation activation control loop. Transcription activity is presumed to be determined by the concentration of protein-specific fragments (PSF) occurring as(More)
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