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  • Michele Baccarani, Jorge Cortes, +17 authors Rȕdiger Hehlmann
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2009 (First Publication: 10 December 2009)
  • PURPOSE To review and update the European LeukemiaNet (ELN) recommendations for the management of chronic myeloid leukemia with imatinib and second-generation tyrosine kinase inhibitors (TKIs),Continue Reading
  • Michele Baccarani, Giuseppe Saglio, +16 authors Rȕdiger Hehlmann
  • Medicine
  • Blood
  • 2006 (First Publication: 15 September 2006)
  • The introduction of imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML). Although experience is too limited to permit evidence-based evaluation of survival, theContinue Reading
  • Charles L. Sawyers, A. Hochhaus, +28 authors Brian J. Druker
  • Medicine
  • Blood
  • 2002 (First Publication: 15 May 2002)
  • Blast crisis is the most advanced stage of chronic myelogenous leukemia (CML) and is highly refractory to therapy. CML is caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene, theContinue Reading
  • Moshe Talpaz, Richard T. Silver, +19 authors Charles L. Sawyers
  • Medicine
  • Blood
  • 2002 (First Publication: 15 March 2002)
  • Chronic myelogenous leukemia (CML) is caused by expression of the BCR-ABL tyrosine kinase oncogene, the product of the t(9;22) Philadelphia translocation. Patients with CML in accelerated phase haveContinue Reading
  • Alois Gratwohl, Jo Hermans, +11 authors Jane F Apperley
  • Medicine
  • Lancet
  • 1998
  • BACKGROUND Transplantation of blood or bone-marrow stem cells is the treatment of choice for selected patients with chronic myeloid leukaemia (CML). Transplantation is used with increasing frequencyContinue Reading
  • Rüdiger Hehlmann, Michael Lauseker, +17 authors Susanne Saussele
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2011 (First Publication: 20 April 2011)
  • PURPOSE Treatment of chronic-phase (CP) chronic myeloid leukemia (CML) with imatinib 400 mg/d can be unsatisfactory. Optimization of treatment is warranted. PATIENTS AND METHODS In all, 1,014 newlyContinue Reading
  • Riccardo Saccardi, Tomáš Kozák, +38 authors Giovanni Luigi Mancardi
  • Medicine
  • Multiple sclerosis
  • 2006 (First Publication: 1 November 2006)
  • Over the last decade, hematopoietic stem cells transplantation (HSCT) has been increasingly used in the treatment of severe progressive autoimmune diseases. We report a retrospective survey of 183Continue Reading
  • Albert N. Békássy, Jo Hermans, Norbert Claude Gorin, Alois Gratwohl
  • Medicine
  • Bone marrow transplantation
  • 1996 (First Publication: 1 May 1996)
  • In a retrospective analysis we assessed occurrence, contributing factors and outcome of patients experiencing granulocytic sarcoma as a localized extramedullary relapse after allogeneic BMT. EBMTContinue Reading