Almohanad A. Alkayyal

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Natural killer (NK) cell clearance of tumor cell emboli following surgery is thought to be vital in preventing postoperative metastases. Using a mouse model of surgical stress, we transferred surgically stressed NK cells into NK-deficient mice and observed enhanced lung metastases in tumor-bearing mice as compared with mice that received untreated NK cells.(More)
PURPOSE Surgical removal of solid primary tumors is an essential component of cancer treatment. Surgery-induced dysfunction in natural killer (NK) cells has been linked to the development of metastases in animal models and patients with cancer. We investigated the activation of NK cells using influenza vaccine in the perioperative period to eradicate(More)
This study characterizes the ability of novel oncolytic rhabdoviruses (Maraba MG1) to boost natural killer (NK) cell activity. Our results demonstrate that MG1 activates NK cells via direct infection and maturation of conventional dendritic cells. Using NK depletion and conventional dendritic cells ablation studies in vivo, we established that both are(More)
Tumors are complex ecosystems composed of networks of interacting 'normal' and malignant cells. It is well recognized that cytokine-mediated cross-talk between normal stromal cells, including cancer-associated fibroblasts (CAFs), vascular endothelial cells, immune cells, and cancer cells, influences all aspects of tumor biology. Here we demonstrate that the(More)
Running Title: Perioperative influenza vaccine enhances NK cell function Perioperative influenza vaccination reduces post-operative metastatic disease by reversing surgery-induced dysfunction in natural killer cells Lee-Hwa Tai, Jiqing Zhang, Karen J. Scott, Christiano Tanese de Souza, Almohanad A. Alkayyal, Anu Abhirami Ananth, Shalini Sahi, Robert A.(More)
Surgical resection is an essential treatment for most cancer patients, but surgery induces dysfunction in the immune system and this has been linked to the development of metastatic disease in animal models and in cancer patients. Preclinical work from our group and others has demonstrated a profound suppression of innate immune function, specifically NK(More)
Despite improvements in chemotherapy and radical surgical debulking, peritoneal carcinomatosis (PC) remains among the most common causes of death from abdominal cancers. Immunotherapies have been effective for selected solid malignancies, but their potential in PC has been little explored. Here, we report that intraperitoneal injection of an infected cell(More)
Anti-tumor CD8+ T cells are a key determinant for overall survival in patients following surgical resection for solid malignancies. Using a mouse model of cancer vaccination (adenovirus expressing melanoma tumor-associated antigen (TAA)-dopachrome tautomerase (AdDCT) and resection resulting in major surgical stress (abdominal nephrectomy), we demonstrate(More)
“Cancer Research Society, Operating Grant” was omitted from the Financial Disclosure of the published article. The correct Financial Disclosure is: This work was supported by Terry Fox Research Institute, New Investigator Award (RCA); Canadian Institutes of Health Research Fellowship (LHT); Canadian Cancer Society Research Institute, Innovation and(More)
Purpose: Surgical removal of solid primary tumors is an essential component of cancer treatment. Surgery-induced dysfunction innatural killer (NK) cells has been linked to the development ofmetastases in animalmodels andpatientswith cancer.We investigated the activationofNKcells using influenza vaccine in the perioperative period to eradicate(More)