Allyson K. Bloom
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Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection
Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid and cost-effective approach to sensitively characterize rapidly evolving… Expand
Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory
The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence… Expand
Glucocorticoid responsiveness of the rat phenylethanolamine N-methyltransferase gene.
Two newly identified, overlapping (1 bp) glucocorticoid response elements (GREs) at -759 and -773 bp in the promoter of the rat phenylethanolamine N-methyltransferase (PNMT; EC 188.8.131.52) gene are… Expand
Treatment of hepatitis C virus–associated mixed cryoglobulinemia with direct‐acting antiviral agents
Hepatitis C virus (HCV) is the most common cause of mixed cryoglobulinemia syndrome (MCS). The efficacy and safety of all‐oral direct‐acting antiviral (DAA) therapy in HCV‐associated MCS (HCV‐MCS) is… Expand
Compensatory Mutations Restore the Replication Defects Caused by Cytotoxic T Lymphocyte Escape Mutations in Hepatitis C Virus Polymerase
- C. Oniangue-Ndza, T. Kuntzen, +15 authors T. Allen
- Biology, Medicine
- Journal of Virology
- 31 August 2011
ABSTRACT While human leukocyte antigen B57 (HLA-B57) is associated with the spontaneous clearance of hepatitis C virus (HCV), the mechanisms behind this control remain unclear. Immunodominant CD8+ T… Expand
Peliosis Hepatis following treatment with androgen-steroids in patients with bone marrow failure syndromes
Androgens widely used in the treatment of bone marrow failure syndromes can in rare cases cause hepatic peliosis, a pathological entity characterized by multiple blood-filled cavities in the liver… Expand
Treatment of Hepatitis C Virus-Associated Mixed Cryoglobulinemia with Sofosbuvir-Based Direct-Acting Antiviral Agents.
Abstract Hepatitis C virus (HCV) is the most common cause of mixed cryoglobulinemia syndrome (MCS). The efficacy and safety of all-oral directly-acting antiviral (DAA) therapy in HCV-associated MCS… Expand
Phenylethanolamine N-Methyltransferase Gene Expression
- S. Her, R. Bell, A. Bloom, B. Siddall, D. Wong
- Medicine, Biology
- The Journal of Biological Chemistry
- 26 March 1999
PhenylethanolamineN-methyltransferase (PNMT) promoter-luciferase reporter gene constructs (pGL3RP863, pGL3RP444, and pGL3RP392) transfected into COS1, RS1, PC12, NIH/3T3, or Neuro2A cells showed the… Expand
Repeat hepatitis B vaccination may lead to seroprotection in HIV-infected patients who do not respond to an initial series.
Approach to the adult with acute diarrhea in developed countries
Most cases of acute diarrhea are due to infections with viruses and bacteria and are self-limited. Noninfectious etiologies become more common as the course of the diarrhea persists and becomes… Expand