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Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection
Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid and cost-effective approach to sensitively characterize rapidly evolvingExpand
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Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory
The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influenceExpand
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Glucocorticoid responsiveness of the rat phenylethanolamine N-methyltransferase gene.
Two newly identified, overlapping (1 bp) glucocorticoid response elements (GREs) at -759 and -773 bp in the promoter of the rat phenylethanolamine N-methyltransferase (PNMT; EC gene areExpand
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Treatment of hepatitis C virus–associated mixed cryoglobulinemia with direct‐acting antiviral agents
Hepatitis C virus (HCV) is the most common cause of mixed cryoglobulinemia syndrome (MCS). The efficacy and safety of all‐oral direct‐acting antiviral (DAA) therapy in HCV‐associated MCS (HCV‐MCS) isExpand
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Compensatory Mutations Restore the Replication Defects Caused by Cytotoxic T Lymphocyte Escape Mutations in Hepatitis C Virus Polymerase
ABSTRACT While human leukocyte antigen B57 (HLA-B57) is associated with the spontaneous clearance of hepatitis C virus (HCV), the mechanisms behind this control remain unclear. Immunodominant CD8+ TExpand
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Peliosis Hepatis following treatment with androgen-steroids in patients with bone marrow failure syndromes
Androgens widely used in the treatment of bone marrow failure syndromes can in rare cases cause hepatic peliosis, a pathological entity characterized by multiple blood-filled cavities in the liverExpand
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Treatment of Hepatitis C Virus-Associated Mixed Cryoglobulinemia with Sofosbuvir-Based Direct-Acting Antiviral Agents.
Abstract Hepatitis C virus (HCV) is the most common cause of mixed cryoglobulinemia syndrome (MCS). The efficacy and safety of all-oral directly-acting antiviral (DAA) therapy in HCV-associated MCSExpand
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Phenylethanolamine N-Methyltransferase Gene Expression
PhenylethanolamineN-methyltransferase (PNMT) promoter-luciferase reporter gene constructs (pGL3RP863, pGL3RP444, and pGL3RP392) transfected into COS1, RS1, PC12, NIH/3T3, or Neuro2A cells showed theExpand
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Approach to the adult with acute diarrhea in developed countries
Most cases of acute diarrhea are due to infections with viruses and bacteria and are self-limited. Noninfectious etiologies become more common as the course of the diarrhea persists and becomesExpand
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