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Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.
Limb anomalies are important birth defects that are incompletely understood genetically and mechanistically. GLI3, a mediator of hedgehog signaling, is a genetic cause of limb malformations includingExpand
Identification of a Novel ZIC3 Isoform and Mutation Screening in Patients with Heterotaxy and Congenital Heart Disease
Patients with heterotaxy have characteristic cardiovascular malformations, abnormal arrangement of their visceral organs, and midline patterning defects that result from abnormal left-rightExpand
Zic3 is required in the migrating primitive streak for node morphogenesis and left-right patterning.
In humans, loss-of-function mutations in ZIC3 cause isolated cardiovascular malformations and X-linked heterotaxy, a disorder with abnormal left-right asymmetry of organs. Zic3 null mice recapitulateExpand
Heterotaxy-spectrum heart defects in Zic3 hypomorphic mice
Background:Mutations in Zinc Finger Protein of the Cerebellum 3 (ZIC3) cause X-linked heterotaxy and isolated cardiovascular malformations. Recent data suggest a potential cell-autonomous role forExpand
ELIGULUM-A Regulates Lateral Branch and Leaf Development in Barley1[OPEN]
The barley ELIGULUM-A gene regulates lateral branch development and acts to establish the blade-sheath boundary during leaf development. The shoot apical and axillary meristems control shootExpand
A Mouse Model of Conduction System Patterning Abnormalities in Heterotaxy Syndrome
Duplication or absence of parts of the specialized cardiac conduction system in patients with heterotaxy syndrome causes significant clinical disease, but the mechanistic basis by which embryonicExpand
A mouse model of conduction system patterning abnormalities in heterotaxy syndrome.
Duplication or absence of parts of the specialized cardiac conduction system in patients with heterotaxy syndrome causes significant clinical disease, but the mechanistic basis by which embryonicExpand
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