Allison L. Wyand

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Retroviral capsid recognition by Trim5 blocks productive infection. Rhesus macaques harbor three functionally distinct Trim5 alleles: Trim5α(Q) , Trim5α(TFP) and Trim5(CypA) . Despite the high degree of amino acid identity between Trim5α(Q) and Trim5α(TFP) alleles, the Q/TFP polymorphism results in the differential restriction of some primate lentiviruses,(More)
Retroviral capsid recognition by Trim5 blocks productive infection. Rhesus macaques harbor three functionally distinct Trim5 alleles: Trim5a, Trim5a and Trim5. Despite the high degree of amino acid identity between Trim5a and Trim5a alleles, the Q/TFP polymorphism results in the differential restriction of some primate lentiviruses, suggesting these alleles(More)
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