Allison Goins

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Fragments of C5 that are generated at, or administered to, extravascular sites in the pulmonary parenchyma induced neutrophil infiltration, edema, tissue damage, and a complete inflammatory response. Generation of C5 fragments within the vascular system induced leukocyte sequestration in the pulmonary vasculature, but without detectable increased vascular(More)
13S contribute to regulation of epithelial permeability.56 We asked whether endothelial cell cytoskeletons could contribute to regulation of endothelial permeability and whether this might have any relationship to granulocyte-mediated increases in lung microvascular permeability. To answer these questions, we used 2 models to measure endothelial(More)
We demonstrated a simple and facile approach to fabricate biocompatible monodisperse hollow microparticles of controlled geometry. The hemispherical, spherical, and cubical microparticles are obtained by drying multilayer capsules of hydrogen-bonded poly(N-vinylpyrrolidone)/tannic acid (PVPON/TA)n. Drying spherical capsules results in hemispherical(More)
Systemic activation of the complement system results in the generation of chemotactic factors that have been suggested to play a role in the pathogenesis of inflammatory pulmonary diseases such as the adult respiratory distress syndrome. This led us to ask whether systemic complement activation by cobra venom factor (CVF) or intravascularly administered(More)
We investigated the influence of drone size and potential reproductive quality on caste interactions by adding large drones reared in drone cells (DC drones; considered to be of higher quality) and small drones reared in worker cells (WC drones; of lower quality) to two observation colonies and monitoring worker–drone interactions and acceptance by workers.(More)
Wound care is one of the leading health care problems in the United States costing billions of dollars yearly. Annually, millions of acute wounds occur due to surgical procedures or traumas such as burns and abrasions, and these wounds can become non-healing due to bacterial infection or underlying pathologies. Current wound care treatments include the use(More)
During inflammation, neutrophils migrate out of blood vessels into the surrounding tissues. A number of studies in vivo have indicated that chemotactic factors, particularly fragments derived from the fifth component of complement, are able to mediate this emigration. The ability of C5 fragments to induce migration of neutrophils through the endothelium and(More)
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