Allison Curtis

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This article describes an energy-based approach to protein adsorption, focusing on the energies involved in the interactions between a protein and a surface. Mathematical modeling and simulation based on this approach allow an improved understanding of the conditions that favor or prevent adsorption of a protein onto a surface and that can play a(More)
The study of protein interactions with surfaces is important in many branches of biomedical engineering. A computer model has been set up in order to aid the understanding and prediction of the likelihood of protein adsorption at a surface and of coagulation between two proteins. In this model, a protein is represented as a hard sphere, neglecting(More)
[1] We use neural networks to find 1-dimensional marginal probability density functions (pdfs) of global crustal parameters. The information content of the full posterior and prior pdfs can quantify the extent to which a parameter is constrained by the data. We inverted fundamental mode Love and Rayleigh wave phase and group velocity maps for pdfs of(More)
This article describes an energy-based approach to protein adsorption, focusing on the energies involved in the interactions between a protein and a surface. Mathematical modeling and simulation based on this approach allow an improved understanding of the conditions that favor or prevent adsorption of a protein onto a surface and that can play a(More)
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the analysis of erythromycin in human plasma (EDTA as anticoagulant) was developed and validated. The concentration ranges were 0.5-50 and 50-5000 ng ml-1. The procedure involved alkalization of 0.5 ml of plasma, one step liquid-liquid extraction, dryness of the extract and(More)
Micropatterned cocultures are a useful experimental tool for the study of cell-cell interactions. Patterning methods often rely on sequential seeding of different cell types or removal of a barrier separating two populations, but it is difficult to pattern sharp interfaces between pure populations with low cross-contamination when using these approaches.(More)
The influence of solvent type on the solution thermodynamics, nucleation-kinetics and crystal growth of alpha para-aminobenzoic acid (PABA) crystallising from supersaturated ethanol, acetonitrile and water solutions, is examined using poly-thermal analysis of the metastable zone width. Application of a recently proposed model for analysis of crystallisation(More)
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