Allison A Forni

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Benzene exposure can induce chromosome aberrations in somatic cells (lymphocytes and bone marrow cells) of man and of experimental animals in vivo, as well as in some in vitro systems. Numerical and structural chromosome changes in bone marrow cells have been described in subjects with benzene haemopathy. Increased rates of structural chromosomal(More)
Medication errors have been increasingly recognized as a major cause of iatrogenic illness and system-wide improvements have been the focus of prevention efforts. Critically ill patients are particularly vulnerable to injury resulting from medication errors because of the severity of illness, need for high risk medications with a narrow therapeutic index(More)
PURPOSE Antiepileptics used for seizure prophylaxis after traumatic brain injury (TBI) are reviewed. SUMMARY Of the 275,000 people who are hospitalized with TBI each year, approximately 5-7% experience a posttraumatic seizure (PTS). According to the latest guidelines issued by the Brain Trauma Foundation and the American Academy of Neurology (AAN) for the(More)
The available data on the possible effects of lead on mammalian chromosomes are reviewed. Several studies of cultured lymphocytes of man and non-human mammals exposed to excess lead show increased rates of chromatid and chromosome aberrations, while other studies are negative. In vitro exposure of lymphocytes to lead acetate also give conflicting results.(More)
BACKGROUND No previous studies exist examining implementation of an institution-wide guideline and order set for hyperglycemic emergencies (diabetic ketoacidosis [DKA] and hyperosmolar hyperglycemic state [HHS]). OBJECTIVE Evaluate the impact of an institutional guideline and order set for hyperglycemic emergencies. METHODS This retrospective(More)
Despite regular use of drugs for critically ill patients, overall data are limited regarding the impact of critical illness on pharmacokinetics (PK). Designing safe and effective drug regimens for patients with critical illness requires an understanding of PK. This article reviews general principles of PK, including absorption, distribution, metabolism, and(More)
BACKGROUND An organized and uniform approach to managing sedation in critically ill patients has been associated with improved outcomes, but the most effective means of optimizing sedative medication use in clinical practice has not been fully determined. Pharmacist interventions directed at improving sedation guideline compliance have been shown to reduce(More)