Allen Paul Nichols

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Vincristine (VCR) has been shown to enhance the trans port of methotrexate (MTX) in animal systems and in acute myelogenous leukemia cells in vitro. In this report, the uptake of MTX and the effect of VCR were studied in two human lymphoblastoid cell lines grown in tissue culture. The effect of VCR on MTX suppression of deoxyuridine incorporation into DNA(More)
In vivo studies were performed in mice bearing L1210 ascites tumor to examine the interaction of vincristine (VCR) at doses of 0.15 and 1.5 mg/kg with methotrexate (MTX) at doses of 0.5, 5, 50, and 350 mg/kg. The combination was administered on Days 2, 6, and 10 after tumor inoculation. VCR was given either concurrently with MTX or preceding it by 30, 60,(More)
Graphics Processing Units (GPUs) have proven to be a powerful and efficient computational platform. An increasing number of applications are demanding more efficient computing power at a lower cost. The modern GPU can natively perform thousands of parallel computations per clock cycle. Relative to the traditional power of a CPU, the GPU can far out-perform(More)
To investigate the potential influence of albumin on the antitumor effect of vincristine (VCR), cells from a human lymphoblastic leukemia cell line (CEM) were exposed in vitro to albumin and a clinically attainable VCR concentration (10(-7)M). Increasing concentrations of albumin between 1 and 4 g/100 ml resulted in a corresponding reduction of VCR-induced(More)
This study analyzes variables associated with syphilis infection among adolescents attending a public medical clinic in the District of Columbia. All adolescent clinic patients found to have Treponema pallidum antibody from June 1, 1989 through June 1, 1990 were included in the study. Medical records were reviewed for the following data: age, sex, presence(More)
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