Allen Macpherson

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This study was designed to evaluate whether hair calcium concentration reflects the mortality from coronary heart disease on a UK-wide basis and to determine the effect--if any--of environmental factors which might affect calcium metabolism on this relationship. The study was based on our earlier findings of an inverse relationship between hair calcium(More)
Three methods of selenium supplementation, by subcutaneous injection, intraruminal pellet and addition to water, were tested in experiments with cattle and a fourth method, oral supplementation of a sodium selenite solution, was evaluated with lambs. All four methods worked effectively for periods ranging from four months to one year after treatment. It is(More)
Hair calcium concentration is biologically regulated and inversely correlated to the concentration in the aorta. Populations generally divide into high and low hair calcium groups which differ significantly from each other. It has been found that about 90% of people who suffer an acute myocardial infarction belong to the low hair calcium group. It follows(More)
Two endothelin antagonists, ZD1611 (3-[4-[3-(3-methoxy-5-methylpyrazin-2-ylsulfamoyl)-2-pyridyl]phenyl]-2,2-dimethylpropanoic acid) and ZD2574 (2-(4-isobutylphenyl)-N-(3-methoxy-5-methylpyrazin-2-yl)pyridine-3-sulfonamide), selective for the ET(A) receptor and intended for use in pulmonary hypertension, were tested in Beagle dogs at various doses for(More)
Two trials involving housed cattle examined the effect of Co depletion and supplementation on immune status as assessed by the neutrophil function test which measures the ability of isolated neutrophils to kill the yeast Candida albicans. A third trial investigated the extent to which Co status influenced the severity of Ostertagia ostertagi infection. In(More)
The selenium content of the 1989 harvest of wheat used for bread making in Scotland ranged from 0.028 microgram/g dry weight for home-grown wheat to 0.518 microgram/g for Canadian wheat. The tonnage values indicate that 13.8% of the wheat used in bread making came from Canada. This reflects in a calculated dietary intake of 31 micrograms/d which is well(More)
We report a case of severe carcinoma-associated dermatomyositis which, having shown no response to conventional treatment, improved markedly within 48 h of plasmapheresis. We believe that this is the first time that dermatomyositis associated with an advanced carcinoma has been reported to respond in this way. Dermatomyositis can prove extremely difficult(More)