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Governance of social-ecological systems is a major policy problem of the contemporary era. Field studies of fisheries, forests, and pastoral and water resources have identified many variables that influence the outcomes of governance efforts. We introduce an experimental environment that involves spatial and temporal resource dynamics in order to capture(More)
Agent-based modelling has become an increasingly important tool for scholars studying social and social-ecological systems, but there are no community standards on describing, implementing, testing and teaching these tools. This paper reports on the establishment of the Open Agent-Based Modelling Consortium, www.openabm.org, a community effort to foster the(More)
Org 26576 acts by modulating ionotropic AMPA-type glutamate receptors to enhance glutamatergic neurotransmission. The aim of this Phase 1b study (N=54) was to explore safety, tolerability, pharmacokinetics, and pharmacodynamics of Org 26576 in depressed patients. Part I (N=24) evaluated the maximum tolerated dose (MTD) and optimal titration schedule in a(More)
Mammalian cerebral cortex is accepted as being critical for voluntary motor control, but what functions depend on cortex is still unclear. Here we used rapid, reversible optogenetic inhibition to test the role of cortex during a head-fixed task in which mice reach, grab, and eat a food pellet. Sudden cortical inhibition blocked initiation or froze execution(More)
OBJECTIVE A growing body of evidence supports the efficacy of D-cycloserine (DCS), a partial agonist at the N-methyl-D-aspartate (NMDA) glutamate receptor, as augmentation to cognitive-behavioral therapy (CBT) in the treatment of anxiety disorders. Org 25935 is a glycine transporter 1 inhibitor that acts to increase synaptic glycine levels and enhance(More)
Experimental data from a spatially explicit dynamic commons dilemma experiment is used to empirically ground an agent-based model. Four distinct patterns are identified in the data. Two naïve models, random walk and greedy agents, do not match the patterns. A more comprehensive model is presented that explains how agents make movement and harvest decisions.(More)
Geographically distributed workgroups are increasingly collaborating on time-sensitive, highly interdependent tasks that require detailed coordination to achieve success; although success under these conditions is often difficult. Improving these collaborations requires both better support from communication and information tools and a better understanding(More)
Software is data, but it is not just data. While " data " in computing and information science can refer to anything that can be processed by a computer, software is a special kind of data that can be a creative, executable tool that operates on data. However, software and data are similar in that they both traditionally have not been cited in publications.(More)