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Driven by market demand, many biological and synthetic scaffolds have been developed during the last 15 years. Both positive and negative results have been reported in clinical applications for tendon and ligament repair. To obtain data for this review, multiple electronic databases were used (e.g., Pubmed and ScienceDirect), as well as the US FDA website(More)
The anatomic and functional effects of clavicle malunion, defined as 15 mm of shortening, were evaluated in 10 subjects. Bilateral shoulder computed tomography with 3-dimensional reconstructions was performed. A self-administered questionnaire was completed, and biomechanical testing of subjects was undertaken comparing strength and velocity of movement(More)
Many new therapeutics for Alzheimer's disease delay the accumulation of amyloid-β (Aβ) in transgenic mice, but evidence for clearance of preexisting plaques is often lacking. Here, we demonstrate that anti-Aβ immunotherapy combined with suppression of Aβ synthesis allows significant removal of antecedent deposits. We treated amyloid-bearing tet-off APP(More)
The purpose of this prospective, randomized study was to apply an 8-week customized exercise program to patients (Group E) scheduled for total hip arthroplasty, followed by a postsurgery exercise program, and show the effect on functional recovery compared with control subjects (Group C) who received no additional exercise apart from routine in-hospital(More)
BACKGROUND Tendon-bone healing after rotator cuff repair directly correlates with a successful outcome. Biological therapies that elevate local growth-factor concentrations may potentiate healing after surgery. PURPOSE To ascertain whether postoperative and repeated application of platelet-rich plasma (PRP) to the tendon repair site improves early tendon(More)
OBJECTIVE Patients with endstage hip arthritis have poor ambulatory function. The aim of this study was to determine if perioperative exercise programs are well tolerated by these elderly patients and if a customized program can achieve an earlier recovery of normal ambulatory function after total hip arthroplasty. DESIGN Twenty-eight subjects scheduled(More)
HYPOTHESIS Despite its common occurrence, lateral epicondylitis is poorly understood from a cellular and molecular perspective. We hypothesize that apoptosis and autophagic cell death are involved in the development of chronic lateral epicondylitis. MATERIALS AND METHODS In 10 patients undergoing surgery for chronic recalcitrant lateral epicondylitis,(More)
The aim of this study was to investigate the relationship between the disruption of ECM and cellular events including autophagic cell death, apoptosis and cell differentiation into myofibroblasts in the degenerative rotator cuff tendon. Tendon samples were collected from 30 patients undergoing surgery for rotator cuff tears. Apoptosis, autophagic cell death(More)
BACKGROUND Severe chronic lateral epicondylitis (LE) is associated with degenerative tendon changes, extracellular matrix breakdown, and tendon cell loss. On the basis of positive outcomes from preclinical studies, this study is the first clinical trial of autologous tenocyte injection (ATI) on severe tendinopathy associated with chronic LE. HYPOTHESIS(More)
Ultra-low power microsystems are gaining interest due to their applicability in critical areas of societal need. Power management in these microsystems is a major challenge as a relatively high battery voltage (ex: 4V) must be downconverted to several low supplies, such as 0.6V for near-threshold digital circuits and 1.2V for analog circuits [1].(More)