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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
TLDR
A set of Cre reporter mice with strong, ubiquitous expression of fluorescent proteins of different spectra is generated and enables direct visualization of fine dendritic structures and axonal projections of the labeled neurons, which is useful in mapping neuronal circuitry, imaging and tracking specific cell populations in vivo.
Genome-wide atlas of gene expression in the adult mouse brain
TLDR
An anatomically comprehensive digital atlas containing the expression patterns of ∼20,000 genes in the adult mouse brain is described, providing an open, primary data resource for a wide variety of further studies concerning brain organization and function.
An anatomically comprehensive atlas of the adult human brain transcriptome
TLDR
A transcriptional atlas of the adult human brain is described, comprising extensive histological analysis and comprehensive microarray profiling of ∼900 neuroanatomically precise subdivisions in two individuals, to form a high-resolution transcriptional baseline for neurogenetic studies of normal and abnormal human brain function.
A mesoscale connectome of the mouse brain
TLDR
A brain-wide, cellular-level, mesoscale connectome for the mouse, using enhanced green fluorescent protein-expressing adeno-associated viral vectors to trace axonal projections from defined regions and cell types, and high-throughput serial two-photon tomography to image the EGFP-labelled axons throughout the brain.
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
TLDR
The robust, consistent and inducible nature of the ChR2 mice represents a significant advance over previous lines, and the Arch-ER2 and eNpHR3.0 mice are to the authors' knowledge the first demonstration of successful conditional transgenic optogenetic silencing.
Transcriptional Landscape of the Prenatal Human Brain
TLDR
An anatomically comprehensive atlas of the mid-gestational human brain is described, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging (MRI) and microarray analysis on highly discrete laser-microdissected brain regions.
Shared and distinct transcriptomic cell types across neocortical areas
TLDR
This study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex and identifies 133 transcriptomic types of glutamatergic neurons to their long-range projection specificity.
Canonical Genetic Signatures of the Adult Human Brain
TLDR
Genes in neuron-associated compared to non-neuronal networks showed higher preservation between human and mouse; however, many diversely patterned genes displayed marked shifts in regulation between species.
Conserved cell types with divergent features in human versus mouse cortex
TLDR
RNA-sequencing analysis of cells in the human cortex enabled identification of diverse cell types, revealing well-conserved architecture and homologous cell types as well as extensive differences when compared with datasets covering the analogous region of the mouse brain.
The Allen Brain Atlas: 5 years and beyond
TLDR
The Allen Brain Atlas, a Web-based, genome-wide atlas of gene expression in the adult mouse brain, was an experiment on a massive scale and has set the stage for the creation of other similar open resources.
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