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The ageing process is associated with important changes in the responses of the cardiovascular system to pharmacological stimuli. They are not limited to the arterial system, involved in the modulation of cardiac afterload and vascular resistance, but they also involve the low-resistance capacitance venous system and the heart. The main changes include loss(More)
BACKGROUND AND PURPOSE Although therapeutic anticoagulation improves early (within 1 month) outcomes after ischemic stroke in hospital-admitted patients with atrial fibrillation, no information exists on late outcomes in unselected population-based studies, including patients with all stroke (ischemic and hemorrhagic). METHODS We identified patients with(More)
The Federal Systems Division of IBM is in the midst of a significant program to provide its software personnel advanced education in the use of modern software engineering practices. Most of today's computer science graduates have a far greater understanding of these advances, their mathematical basis and their application, than do programmers in industry,(More)
There is increasing recognition that aging can have a profound effect on the presentation of illness. Older patients with diseases of visceral organs are much more likely than younger adults to present atypically. Examples are the frequent absence of pain in older patients with conditions such as myocardial infarction, peptic ulcer disease, and(More)
BACKGROUND Prospective population-based studies are important to accurately determine the incidence and characteristics of stroke associated with atrial fibrillation (AF), while avoiding selection bias which may complicate hospital-based studies. METHODS We investigated AF-associated stroke within the North Dublin Population Stroke Study, a prospective(More)
OBJECTIVES To evaluate the efficacy of treatment of the vasodepressor form of carotid sinus hypersensitivity (carotid sinus syndrome (CSS)) with midodrine. DESIGN A prospective, double-blind, randomized, controlled trial of crossover design. SETTING A dedicated outpatient facility with access to tilt-table, digital arterial photoplethysmography, and(More)
BACKGROUND AND PURPOSE Transient ischemic attack (TIA) etiologic data and the ABCD(2) score may improve early stroke risk prediction, but studies are required in population-based cohorts. We investigated the external validity of the ABCD(2) score, carotid stenosis, and atrial fibrillation for prediction of early recurrent stroke after TIA. METHODS(More)
PURPOSE The incidence of osteoporosis-related fractures will increase substantially over the coming decades as the population ages globally. This has important economic and public health implications, contributing substantially to morbidity and excess mortality in this population. METHODS When prescribing for older patients the effectiveness profile of(More)
BACKGROUND AND PURPOSE Reliable etiologic classification of ischemic stroke may enhance clinical trial design and identification of subtype-specific environmental and genetic risk factors. Although new classification systems (Causative Classification System [CCS] and ASCO [A for atherosclerosis, S for small vessel disease, C for cardiac source, O for other(More)
BACKGROUND AND PURPOSE Transient ischemic attack (TIA) diagnosis is frequently difficult in clinical practice. Noncerebrovascular symptoms are often misclassified as TIA by nonspecialist physicians. Clinical prediction rules such as ABCD(2) improve the identification of patients with TIA at high risk of early stroke. We hypothesized that the ABCD(2) score(More)